Ni Made Amelia R. Dewi, Budi Suprapti, I Gde Raka Widiana


Reuse of dialyzers for hemodialysis can help in bringing down the cost of hemodialysis. On the other hand reuse of dialyzer may change dialyzer integrity. This study was undertaken to determine dialyzer reuse effect on Urea Reduction Ratio (URR), Kt/V urea and serum albumin. This was prospective study in Sanglah Public General Hospital Denpasar. Inclusion criteria for this study were patients who receive hemodialysis more than 3 months on twice weekly hemodialysis. In the study we used hollow fiber or dialyzer Elisio type H-130H reprocessed with Renaline automatically by machine renatron.  After each session blood urea, post dialysis weight and serum albumin were measured. Measurements was performed on the use new dialyzer, 1st reuse, 4th reuse and 7th reuse. The dialyzer was discarded, if TCV fell below 80% of baseline value. Kt/V and urea reduction ratio (URR) were calculated as measure of dialysis adequacy. A total of 23 people completed the study. There was a lack of uniformity duration of hemodialysis, so that we also performed an analysis using a uniform length hemodialysis duration (4.5 hours) with 15 samples. There were no significant difference between URR and Kt/V urea of new dialyzer and dialyzer reprocessed by renaline respectfully with p=0.131 and p=0.373. If we analyzed only using uniform time of dialysis (4.5 h) the value of URR and Kt/V urea between new and reused dialyzer not significantly different with p=0.520 and p=0.784. There was also not found significant differences between serum albumin of the use new dialyzer and reused dialyzer by the time of uniform or non-uniform, respectfully with p=0.271 and 0.073. Reuse dialyzer does not alter efficacy of hemodialysis.

Key words : Dialyzer, Urea Reduction Ratio (URR), Kt/V Urea, Albumin, Total Cell Volume (TCV)

Full Text:

PDF (166-170)


Aggarwal HK., Jain D., Shasney A., Bansal T., Yadhav RK., Kathuria KL., 2012. Effect of Dialyser Reuse on the Efficacy of Haemodialysis in Patients of Chronic Kidney Disease in Developing World. JIMSA. 2: 81-83.

Ahmed MH., Abed J., Tarif N., Alam A., Wakeel JS., Memon N et al, 2001. Dialyser reuse impact on dialyser efficiency, patient mortality and cost effectiveness. Saudi J Kidney Dis Transpl : 12:305-311

Azar AT, 2009. Increasing Dialysate Flow Rate Increases Dialyzer Urea Clearance and Dialysis Efficiency An In Vivo Study, Saudi J Kidney Dis. Transplant. 20(6), 1023-1029

Canaud, B. 2004. Adequacy target in hemodialysis. J. Nephrol. 17(8): S77– S86

Cheung AK, Agodoa LY, Daugirdas JT, Depner TA, Gotch FA, Greene T, Levin NW, Leypoldt JK. 1999. Effects of hemodialyzer reuse on clearances of urea and beta2-microglobulin. The Hemodialysis (HEMO) Study Group. J Am Soc Nephrol 10: 117–127

Gotch FA, 1980. Mass Transport in Reused Dialyzers. Proc. Clin. Dial. Transplant. Forum 10, 81–85

Kaplan A., Halley S., Lapkin R, Graeber C, 1980. Dialysate protein losses with bleach processed polysulfone dialyzers. Kidney Int 47: 573–578, 1995

Lobo V,Gang S , Shah LJ, Ganju A, Pandaya PK, Rajapurkar MM et al, 2001. Effect of hollow fiber dialysers reuse upon kt/v(urea). Indian J Nephrol: 12:40-48.

Manandhar DN, Chetri PK, Tiwar Ri, Lamichhane S, 2009. Evaluation of dialysis adequacy in patients underhemodialysis and effectiveness of dialysers reuses. Nepal Med Coll 11: 107-110

Ouseph, R., Hutchison, C.A., Ward, R.A, 2008. Differences in solute removal by two high-flux membranes of nominally similar synthetic polymers. Nephrol. Dial. Transplant. 23(5), 1704–1712

Prihanto E., 2001, Perbandingan Klirens Urea (N) dan Rasio Penurunan Urea (N) Pada Ginjal Buatan Baru dan Ginjal Buatan yang Dipakai Berulang, Thesis, Universitas Diponegoro, Semarang

Rianti T., 2001. Pengaruh Penggunaan Ginjal Buatan (Dialiser) Berulang terhadap Kadar Serum Albumin, Thesis, Universitas Diponegoro, Semarang

DOI: http://dx.doi.org/10.14499/indonesianjpharm25iss3pp166


  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:

analytics View My Stats