Agus Siswanto, Achmad Fudholi, Akhmad Kharis Nugroho, Sudibyo Martono


Aspirin has low solubility in water therefore, dissolution is a rate limiting step for absorption. Floating tablet formulation is designed to improve the bioavailability of aspirin. The objective of this study was to determine in vitro dissolution study of aspirin floating tablet release kinetics model. The floating tablets were prepared by a direct compression method using Methocel K4M CR, NaHCO3, Ethocel, Aerosil, and dicalcium phospate anhydrous as excipients. Tablets were evaluated by different parameters such as physicochemical properties, floating lag time (Flag time), total floating time, and dissolution. The result showed that the tablet mass has good flow properties of 13.54 g/sec. Aspirin floating tablets had a weight uniformity (CV=1.45%), good hardness (6.42kg), and low friability (0.158%). The tablet has a short Flag time of 25.16 sec and long floating time of 8 hours. Dissolution data were evaluated using DDSolver conducted by (1) Statistical parameters: R2adjusted, AIC, MSC; (2) Visual goodness of fit (GOF). The results showed that aspirin floating tablets release kinetics followed the Korsmeyer-Peppas model. Aspirin release occurs through the mechanism of anomalous transport which combines Fickian diffusion and polymer relaxation.

Key words: aspirin floating tablet, DDSolver, modeling of drug release

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Awtry EH., Loscalzo J., 2000, Aspirin, Circulation, 101, 1206-1218

Costa P., Lobo JMS., 2001, Review Modeling and comparison of dissolution profiles, Eur. J.Pharm. Scie., 13,123-133

Colombo P., Santi P., Bettini R., Brazel CS., Peppas NA., 2000, Drug Release from Swelling-Controlled System, in Wise, D.L., Handbook of Pharmaceutical Controlled Technology, Marcel Dekker Inc., New York. pp 183-205

Dave BS., Amin AF., Patel MM., 2004, Gastroretentive Drug Delivery System of Ranitidine Hydrochloride:Formulation and In Vitro Evaluation, AAPS PharmSciTech, 5(2), 1-6

Davies P., 2009, Oral Solid Dosage Form, In Gibson M., Pharmaceutical Preformulation and Formulation, Informa healtcare, New York. pp 389

Fudholi A., 1983, Methodology Formulation in Direct Compression, Medika, 7(9), 586-593

Gopalakrishnan, S., Chenthilnathan, A., 2011, Floating Drug Delivery Systems: A Review, J. Pharm. Scie. Tec., 3(2), 548-554.

Gordon RE., Rosanke TW., Fonner DE., Anderson NR., Banker GS., 1990, Granulation Technology and Tablet Characterization, in Lieberman, H.A., Lachman, L., Schwartz, J.B., Pharmaceutical Dosage Form: Tablet, 2nd Ed., Vol 2, Marcel Dekker Inc., New York. pp 327-332

Gordon MS., Ellis DJ., Molony B., 1994, In Vitro Dissolution Versus In Vivo Evaluation of Four Different Aspirin Products, Drug Dev. Ind. Pharm., 20(10), 1711-1723

Kannan S., Manivannan R., Balasubramaniam A., Kumar NS., 2010, Formulation and Evaluation of Aspirin Delayed Release Tablet, IJCP, 01, accessed 12.02.12,

Kalam MA., Humayun M., Parvez N., Yadaz S., Garg A., Amin S., Sultana Y., Ali A., 2007, Release Kinetics of Modified Pharmaceutical Dosage Forms: A Review, J.Pharm.Sciences, 1, 30-35

Lauer MS., 2002, Aspirin For Primary Prevention of Coronary Events, N Engl J Med, 346(19), 1468-1474

Moffat AC., Osselton MD., Widdop B., Watts J., 2011, Clarke’s Analysis of Drugs and Poisons in Pharmaceuticals, Body Fluids and Postmortem Material, fourth edition, Pharmaceutical Press, London-Chicago. pp 924-926

Motulsky HJ., Christopoulos A., 2003, Fitting Models To Biological Data Using Linear and Nonlinear Regression. A Practical Guide To Curve Fitting, GraphPad Software, Inc., San Diego CA. pp 143-148

Murtaza G., Ahmad M., Khan SA., Hussain I., 2012, Evaluation of Cefixime-Loaded Chitosan Microspheres: Analysis of Dissolution Data Using DDSolver, Dissolution Technologies, 13-19

Nugroho AK., Binnarjo A., Hakim AR., Ermawati Y., 2014, Compartmental Modeling Approach of Losartan Transdermal Transport In Vitro, Indonesian J. Pharm., Vol. 25 No. 1, 31-38

Patel DM., Patel NM., Pandya NN., Jogani, PD., 2007a, Gastroretentive Drug Delivery System of Carbamazepine: Formulation Optimization Using Simplex Lattice Design: A Technical Note, AAPS PharmSciTech, 8(1), E1:E5, accessed 24.10.11,

Patel VF., Patel NM., 2007b, Statistical Evaluation of Influence of Viscosity and Content of Polymer on Dipyridamole Release From Floating Matrix Tablets: A Technical Note, AAPS PharmSciTech, 8(3), E2-E5, accessed 24.10.11,

Patrono C., Rocca B., 2008, Aspirin: Promise and Resistance in the New Millennium, Arterioscler Thromb Vasc Biol, 28, s25-s32, accessed 16.11.11, .

Suratri A., 2008, Floating Drug Delivery Systems To Increase Gastric Retention of Drugs: A Review, RJPT, 1(4), accessed 02.04.11, .

Sweetman SC., 2009, Martindale The Complete Drug Reference, Thirty-sixth edition, Pharmaceutical Press, London. pp 20-25

USP, 2008, United States Pharmacopeial XXXII, accessed 17.02.12, .

Wells J., 2002, Pharmaceutical preformulation: The Physicochemical Properties of Drug Substances, in Aulton, M.E., Pharmaceutics: The Science of Dosage Form Design, Ed. II, Churcihill Livingstone, Edinburg. pp 113-138

Zhang Y., Huo M., Zhou J., Zou A., Li W., Yao C., Xie S., 2010, DDSolver: An Add-In Program for Modeling and Comparison of Drug Dissolution Profiles, The AAPS Journal, Vol. 12 No. 3, 263-271



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