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Tracheospasmolytic activity of vitetrifolin-E isolated from the leaves of Vitex trifolia L.
Abstract
In searching of tracheospasmolytic active compounds from Vitex trifolia, we are now reporting isolation and identification of vitetrifolin-E from active fraction obtained from n-hexane extract of V. trifolia. Vitetrifolin-E blocked spontaneous contraction of male guinea pig trachea induced by histamine and was active in a model using sensitized guinea pig trachea stimulated by ovalbumin. Vitetrifolin-E inhibited tracheal contraction by 22.6% at dose of 1.3 x 10-4 M and by 86.1% at dose of 4.10-4 M. In a model using sensitized male guinea pig trachea, vitetrifolin-E also inhibited the contraction 83.5% (1.3 x 10-5 M).
Keywords: vitetrifolin-E, Vitex trifolia, tracheospasmolytic
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DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp188-194
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