A Preformulation of a Water Soluble Furosemide Dosage Form

Yandi Syukri, Tedjo Yuwono, Lukman Hakim


Solid dispersion system of water-insoluble furosemide in polyvinylpirolidon (PVP) was prepared by a solvent method in various ratios of 1 : 1, 1 : 3, 1 : 5, 1 : 7 and 1 : 9 of the drug and PVP, respectively in order to improve furosemide solubility and dissolution. The improvement of furosemide solubility was studied by a solubility method in a shaking waterbath. The solubility test showed that various concentrations of PVP and temperature gave statistically significant increased of furosemida solubility (P < 0,05). The dissolution study of furosemide solid dispersion system was done using a dissolution tester at the rotation rate of 50 rpm. Furosemide concentration released was determined spectrophotometrically using a UV spectrofometer. This test showed a significant increased of furosemida solubility (P < 0,05), but with a prolonged of releasing time.

Key Word : solid dispersion, solubility, dissolution, bioavailability.

Full Text:



UI Press, Jakarta pp. 124 – 134

Chiou, W.L., and Riegelman, S., 1971, Pharmaceutical Application of Solid Dispersion System, J. Pharm. Sci., 60 (9), 1281-1301

Kelly, M.R., Cutler, R.E., Forrey, A.W., and Kimpel, B.M., 1974, Pharmacokinetics of Orally Administered Furosemide, Clin. Pharmacol. Ther., 15, 178-186

Pan, R. N., Chen, J. H., Chen, R. R. L., 2000, Enhancement of Dissolution and Bioavailability of Piroxicam in Solid Dispersion System, Drug-Dev. Ind. Pharm, 26(9), 989 - 994

Santoso, S., 2000, SPSS, Mengolah Data Statistika Secara Profesional, Gramedia, Jakarta, 371 – 380

Syukri, Y., Ben, E.S., Salman, 2000, Studi Sistem Dispersi Padat Furosemida – Urea, Eksakta, Univ. Islam Indonesia, Yogyakarta

Yalkowsky, S. H., 1981, Techniques of Solubilization of Drugs, Marcel Dekker, New York, 135 – 143.

DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp50-54


  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:

analytics View My Stats