THE INFLUENCE OF AQUEOUS EXTRACT OF CORIANDRI (Coriandrum sativum L) FRUCTUS TO BLOOD GLUCOSE LEVEL IN GLUCOSE- PRE LOADED RATS
Abstract
Coriander contains some active compounds capable of decreasing the level of blood glucose. Moreover, aqueous extract of coriander (Coriandrum sativum L.) fruits has insulin-releasing and insulin-like activities. This research has been performed to obtain information on the effect of aqueous extract of coriander fruits on the blood glucose level in glucose-preloaded rats. The study was conducted by employing a complete random design in male Wistar rats (age 2-2,5 months, 150-250g).After the design treatments, the blood samples were collected (100-200 ul) at certain time interval. The result of each group were compared and analysed using the Mann-Whitney non-parametric method (95%). The result showed that low doses (0.014 and 0.07 % w/v) of aqueous extract of coriander fruits were unable to decrease significantly (p>0.05) the blood glucose level in glucose-preloaded glucose. On the other hand, high doses, 0.35 and 1.75 % w/v, were capable to decrease significantly (p<0.05), which are 22.11 ± 3.09 and 18.41 ± 4.88 %, respectively. Nevertheless, in the present study, the highest hypoglycaemic effect of aqueous extract of coriander fruits still lower than that of tolbutamide (p<0.05).
Keywords: coriander, hypoglycaemic, glucose, tolbutamide
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DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp7-11
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