ATTEMPTED SYNTHESIS OF BIS-SPIROEPOXIDE  DITHIANEDIOXIDE

Ritmaleni Ritmaleni; Varinder K. Aggarwal

doi:10.14499/indonesianjpharm23iss3pp188-192

ATTEMPTED SYNTHESIS OF BIS-SPIROEPOXIDE DITHIANEDIOXIDE

Ritmaleni Ritmaleni, Varinder K. Aggarwal

Abstract

The bis-spiroepoxide dithiane dioxide has been attempted to be synthesised as its role as an intermediate in the synthesis of diaminopimelic acid (DAP). The first method was carried out by reacting the 3-dithiane-2-diethylphosphonate 4 with an aqueous solution of the commercially available glutaraldehide resulting the bis-ketene dithiane dioxide 5. The second alternative method was involving the ozonolysis of cyclopentene 7 in the synthesis of bis-ketene dithiane dioxide 5 in four step reactions which gave moderate to good yield. Unfortunately, epoxidation process for the bis-ketene dithiane dioxide 5 was still unsuccess yet.

Key words: synthesis, diaminopimelic acid, bis-spiroepoxide dithiane dioxide

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DOI: http://dx.doi.org/10.14499/indonesianjpharm23iss3pp188-192