DEVELOPMENT AND EVALUATION OF IN SITU GELS OF  MOXIFLOXACIN FOR THE TREATMENT OF PERIODONTITIS

Hareesh Babu Kunche; Mohammed Gulzar Ahmed; Narayana Charyulu Rompicharla

doi:10.14499/indonesianjpharm23iss3pp141-146

DEVELOPMENT AND EVALUATION OF IN SITU GELS OF MOXIFLOXACIN FOR THE TREATMENT OF PERIODONTITIS

Hareesh Babu Kunche, Mohammed Gulzar Ahmed, Narayana Charyulu Rompicharla

Abstract

Gel dosage forms are successfully used as drug delivery systems to control drug release and protect the medicaments from a hostile environment. The main objective of the present investigation is to formulate and evaluate in situ gels of moxifloxacin for the treatment of periodontitis using gellan gum and sodium alginate based on the concept of ion activated systems. The system utilizes polymers that exhibit sol-to-gel phase transition due to change in specific physico-chemical parameters. Sol-to-gel transformation occurred in the presence of monovalent/divalent cations. It was found that increase in the concentration of calcium ions produced stronger gels. Formulations were evaluated for gelling capacity, drug content, clarity, viscosity, gel strength, spread ability, microbiological studies and in vitro release. The results shown by the above characterization studies were found to be satisfactory. Experimental part showed that viscosity of sols and gel strength was increased with increase in the concentration of polymers and the sustained release of drug was observed. The formulations were therapeutically efficacious, sterile and provided sustained release of the drug over a period of time. These results demonstrated that the developed system is an alternative to conventional drug delivery systems, provides patient compliance and economical.

Key words: in situ gels, moxifloxacin, periodontitis, polymers, Ion activation.

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References

Swati R., Sandeep W., and Swaroop L., 2010, In Situ Gel Formulation of Ornidazole for the Treatment of Periodontal Disease. Curr. Pharm, Res. 1(1): 60-9.

Jemin K., and Salomon A., 2006, Periodontal disease and systemic conditions: a bidirectional relationship. 94(1);10-21.

Mohammed G.A, Narayana CR., Deepak A., Harish NM., and Prabhakar P., 2008, Development and characterization of target retentive polymeric films of gatifloxacin for periodontal infections. J.Chem Pharm Sci.;1(2):56-61.

Mohammed GA., Harish NM., Narayana CR., and Prabhakar P., 2009, Formulation of chitosan-based Ciprofloxacin and Diclofenac film for periodontitis therapy. Trop. J. Pharm Res. 8(1):33-41.

Pragati S., Ashok S., and Kuldeep S., 2009, Recent advances in periodontal drug delivery systems. Int.J. Drug Delivery.1-14.

Nirmal HB., Bakliwal SR., and Pawar SP., 2010, In-Situ gel: New trends in Controlled and Sustained Drug Delivery System. Int. J. Pharm. Tech Res. 2(2):1398-1408.

Vyas J., Ghetia T., Gajjar V., Christian V., and Upadhyay U., 2011, A review on novel in situ polymeric drug delivery systems. IJPRD.;3(5):53-9.

Darlene M. 2008, Review of moxifloxacin hydrochloride ophthalmic solution in the treatment of bacterial eye infections. Clin Ophthalmol., 2(1):77–91.

Ingo S., Georg C., Enno S., Oliver AM., Rainer L., and Ursula P,. 2002, In Vitro Activity of Moxifloxacin against Bacteria Isolated from Odontogenic Abscesses. Antimicrob Agents Chemother.;46(12):4019-21.

Harish NM., Prabhu P., Charyulu RN., Gulzar MA., and Subrahmanyam EVS., 2009, Formulation and Evaluation of in situ Gels Containing Clotrimazole for Oral Candidiasis. Ind. J. Pharm. Sci.; 1(4):421–27.

Shastri DH., Patel LD., Parikh RK., 2010, Studies on In situ hydrogel: A smart way for safe and sustained ocular drug delivery. J. Young Pharmacist.;2(2):116-120.

Himanshu G., Aarti S., 2009, Ion activated bioadhesive in situ gel of clindamycin for vaginal application. Int. J. Drug Del. 32-40.

DOI: http://dx.doi.org/10.14499/indonesianjpharm23iss3pp141-146