Influence of filler-binders on ibuprofen iablets with direct  compression method

Lannie Hadisoewignyo; Gracesya Florensya Teny; Elok Tri Handayani; Beby Yunita

doi:10.14499/indonesianjpharm0iss0pp279-285

Influence of filler-binders on ibuprofen iablets with direct compression method

Lannie Hadisoewignyo, Gracesya Florensya Teny, Elok Tri Handayani, Beby Yunita

Abstract

Ibuprofen is a active ingredient that have low melting point, but it has poor flowability, and poor compactibility, this causes ibuprofen tablets are not suitable to be made by direct compression method. The use of appropiate filler-binders can improved the flow properties and compactibility powder that can be made by direct compression. Filler binders commonly use are Avicel PH 102, Emcompress, SDl, and Starch 1500. Formula tablet ibruprofen using Avicel PH 102 as filler-binder will produce tablet with good hardness, low friability, fast disintegrating, and high dissolution. This is because the hydrophilic properties and plastic deformation which is owned by Avicel PH 102.

Key words:Ibuprofen, Avicel PH 102, direct compression

Full Text:

Untitled

References

Anonim, 1979, Farmakope Indonesia, ed. III, Departemen Kesehatan RI, Jakarta.

Anonim, 1995, Farmakope Indonesia, ed. IV, Departemen Kesehatan RI, Jakarta,.

Banker, G.S., and Anderson, N.R., 1986, Tablets, in: Lachman, L. Lieberman, H.A., and Kanig, J.L. (eds): The Theory and Practise of Industrial Pharmacy, 3rd Ed., Marcel Dekker lnc., New York.

Bolhuis, G.K. and Z.T. Chowman, 1996, Materials Direct Compaction, in: Pharmaceutical Powder Compaction Technology, G. Alderborn and C. Nyström (eds.), Marker Dekker, Inc., New York.

Gohel, M.C., 2005, A Review of Co-Processed Directly Compressible Excipient, J Pharm Pharmaceut Sci, 8 (1), 76-93.

Lund, W. 1994, The Pharmaceutical Codex, 12th, Pharmaceutical Press, London.

Medina, M.D.L.L.R and V. Kumar, 2006, Evaluation of cellulose II powders as a potential multifunctional excipient in tablet formulations, Int. J.Pharm. 322, 31-35.

Peck, G.E., Bailey, G.J., McCurdy, V.E., and Banker, G.S., 1989, Tablet Formulation and Design, 2nd Edition, in:Lieberman, H.A., Lachman, L.,and Schwartz, J.B. (eds.): Pharmaceutical Dosage Form: Tablet, Vol. I, Marcel Dekker Inc., New York.

Rowe, R.C., P.J. Sheskey, and S.C. Owen, 2006, Handbook of Pharmaceutical Excipients, 5th ed., The Pharmaceutical Press, London.

Voigt, R., 1995, Buku Pelajaran Teknologi Farmasi (Soewandhi, S.M., penerjemah), 5th ed., Gadjah Mada University Press, Yogyakarta.

Wells, J.I., 1988, Pharmaceutical Preformulation The Physicochemical Properties of Drug Substances, Ellis Horwood Limited, Great Britain.

DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp279-285