Response to antiretroviral therapy undergone by HIV/AIDS patients

Nanang Munif Yasin, Hesaji Maranty, Wahyu Roossi Ningsih

Abstract


HIV/AIDS,  with  new  cases  thereof  coming  up  year  after  year,  is  a  fastgrowing  disease.  In  order  to  inhibit  HIV  replication,  ARV  is  administered  to HIV/AIDS  patients  throughout  his  life-time.  Continuous  monitoring  for  the detection of its desired result ought to be conducted. This study is aimed to find out  the  response  of  the  ARV  therapy  undergone  by  the  HIV/AIDS  patients hospitalized  in  a  teaching  hospital  in  Yogyakarta.  Descriptive  non-experimental design  was  used  for  the  study.  The  data  were  obtained  retrospectively  from medical records of 71 patients who met the inclusion and exclusion criteria. The data  were  analyzed  descriptively.The  research  findings  indicated  that  of  the first-line  ARV  therapy,  zidovudine+lamivudine+nevirapine  (AZT+3TC+NVP)  was mostly  used  (61.97%).  It  was  found  that  all  of  the  ARV  types  used  were  in accordance  with  the  National  Therapy  Antiretroviral Guidelines  (2007)  from Health  Ministry  Department,  Indonesia.  As  observed  further,  61  (92.80%),  40 (85.00%), and 20 (85.00%) patients had their CD4 increased; 66 (72.72%), 44 (75.00%), 24 (79.17%) had gained weight; and 71 (100%), 55 (100%), and 31 (96.77%) had survived the disease after 6, 12, and 24 months undergoing ARV therapy.  However,  the  increase  in  CD4 after  six-month  therapy  was  not  always attended  by  the  increase  in  weight.  To  conclude,  this  phenomenon  indicated good immune and clinical responses.

Key words: HIV/AIDS, antiretroviral, therapy response, CD4count, hospital

 


Full Text:

Untitled

References


Anonim, 2004, Pedoman Nasional Terapi Antiretroviral, Direktorat Jenderal Pemberantasan Penyakit Menular dan Penyehatan Lingkungan, Departemen Kesehatan Republik Indonesia, Jakarta.

Anonim, 2005, Pedoman Monitoring Pasien untuk Perawatan HIV dan Terapi Antiretroviral (ART), Direktorat Jenderal Pemberantasan Penyakit Menular dan Penyehatan Lingkungan, Departemen Kesehatan Republik Indonesia, Jakarta.

Anonim, 2006a, Pedoman Pelayanan Kefarmasian untuk Orang dengan HIV/AIDS (ODHA), Direktorat

Bina Farmasi Komunitas dan Klinik, Direktorat Jenderal Bina Kefarmasian dan Alat Kesehatan, Departemen Kesehatan Republik Indonesia,Jakarta.

Anonim, 2006b, Antiretroviral Therapy for HIV Infection in Adults and Adolescents: Recommendations for a public health approach, WHO, Geneva.

Anonim, 2007, Pedoman Nasional Terapi Antiretroviral: Panduan Tatalaksana Klinis Infeksi HIV pada Orang Dewasa dan Remaja, Edisi kedua, Direktorat Jenderal Pengendalian Penyakit dan Penyehatan Lingkungan, Departemen Kesehatan Republik Indonesia, Jakarta.

Anonim, 2008a, 2008 Report on the global AIDS epidemic, UNAIDS dan WHO, http://www.kui.no/doc/Fakta%20hiv%20aids/JC1510_2008GlobalReport_en.pdf, 21 Maret 2009.

Anonim, 2008b, Statistik Kasus HIV/AIDS di Indonesia Dilapor s/dDesember 2008, Direktorat Jenderal Pemberantasan Penyakit Menular dan Penyehatan Lingkungan, Departemen Kesehatan Republik Indonesia, http://spiritia.or.id/Stats/StatCurr.pdf, 6 Februari 2009.

Anonim, 2009, Laporan Jumlah Kasus HIV/AIDS di Daerah Istimewa Yogyakarta sampai 31 Desember 2008, Dinas Kesehatan Propinsi DIY, Yogyakarta.

Carey, D., 1998, HIV/AIDS, dalam Hughes, J., Donnelly, R., dan James-Chatgilaov, G., Clinical Pharmacy: A Practical Approach, The Society of Hospital-Pharmacists of Australia,Victoria.

Corey, D.M., Kim, H.W., Salazar, R., Illescas, R., Villena, J., Gutierrez, L., Sanchez, J., and Tabet,S.R., 2007, Effectiveness of Combination Antiretroviral Therapy on Survival and Opportunistic Infections in a Developing World Setting An Observational Cohort Study, J Acquir. Immune Defic. Syndr., 44, 451–455,

Dahlan, M.S., 2008, Statistik untuk Kedokteran dan Kesehatan, Edisi 3, 157, Penerbit Salemba Medika, Jakarta.

Djoerban, Z., 1999, Membidik AIDS: Ikhtiar Memahami HIV dan ODHA, Galang Press bekerjasama dengan Yayasan Memajukan Ilmu Penyakit Dalam, Yogyakarta.

Fletcher, C.V., and Kakuda, T.N., 2005, Human Immunodeficiency Virus Infection, dalam Dipiro, J.T., Talbert, R.I., Yee, G.C., Maatzke, A., Wells, B.G., dan Passey, L.M., Pharmacotherapy: A Pathophysiologic Approach, 6th edition, Appleton and Lange, Philadelphia.

Herfindal, E. T. and Gourley, D. R., 2000, Textbook of Therapeutics : Drug and Disease Management, 1555, 1558, Lippincott Williams & Wilkins, Philadephia.

Hogg, R.S., Yip, B., and Chan, K.J., 2001, Rates ofDisease Progression by Baseline CD4Cell Count and Viral Load after Initiating Triple Drug Therapy, JAMA, 286, 2568-2577.

Hung, C.C., Hsiao, C.F., Chen, M.Y., Hsieh, S.M., Chang, A.Y., Sheng, W.H., Sun, H.Y., and Chang, S.C., 2006, Improved Survival of Persons with Human Immunodeficiency Virus Type 1 Infection in the Era of Highly Active Antiretroviral Therapy in Taiwan,

Jpn. J. Infect. Dis., 59, 222-228.

Indrawati, V., 2008, Hubungan Nilai CD4pada Awal Pengobatan ARV dengan Kemampuan Hidup 1 Tahun Orang dengan HIV/AIDS (ODHA), Tesis, Sekolah Pascasarjana Universitas Gadjah Mada, Yogyakarta.

Jensen-Fangel, S., 2004, The Effectiveness of Highly Active Antiretroviral Therapy in HIV-Infected Patients, Danish Medikal Bulletin, 51 (4), 371-392.

Malvy, D., Thie´baut, R., Marimoutou, C., and Dabis, F., 2001, Weight Loss and Body Mass Index as Predictors of HIV Disease Progression to AIDS in Adults. Aquitaine Cohort France 1985–1997, J. of the American College of Nutrition, 20 (6), 609-615,

Madec, Y., Szumilin, E., Genevier, C., Ferradini, L., Balkan, S., Pujades, M., and Fontanet, A., 2009,Weight Gain at 3 Months of Antiretroviral Therapy is Strongly Associated with Survival: Evidence from Two Developing Countries, AIDS, 27 (7), 853-861.

Messou, E., Gabillard, D., Moh, R., Inwoley, A., Sorho, S., Eholie, S., Rouet, F., Seyler, C., Danel, C., and Anglaret, X., 2008, Anthropometric and Immunological Success of Antiretroviral Therapy and Prediction of Virological Success in West African Adults, Bulletin of the WHO, 86 (6), 435-442.

Nadhiroh, S.R., 2006, Good Nutrition for Quality of Life of PLWHA (People Living with HIV/AIDS), The Ind. J. of Public Health, 3 (2), 29-34.

Olawumi, H.O., Olatunji, P.O., Salami, A.K., Odeigah, L., and Iseniyi, J.O., 2008, Effect of Highly Active Antiretroviral Therapy on CD4 Count and Weight in AIDS Patients Seen at The UITH, Ilorin, Nig. J. of Clin. Pract., 11 (4), 312-315.

Princeton, D.C., 2003, Manual of HIV/AIDS Therapy 2003 Edition, hal 61,63-64, dan 72, Current Clinical Strategies Publishing, California.

Smart, T., 2007, Defining and then Watching for Treatment Failure, dalam Anonim, HATIP 94: Mendefinisikan lalu Mengamati Kegagalan Pengobatan,

Wanke, C., Ostrowsky, B., Gerrior, J., and Hestnes,J., 1998, Effect of Highly Active Antiretroviral Therapy on Patient Weight and Body Mass Index, Int. Conf. AIDS, 12,




DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp212-222

Refbacks

  • There are currently no refbacks.




Copyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:

web
analytics View My Stats