SYNTHESIS AND EVALUATION OF ANTIOXIDANT AND ANTIINFLAMMATORY ACTIVITIES OF 2-(4’-DIMETHYLAMINO BENZYLIDENE)-6-BENZYLIDENE CYCLOHEXANONE

Sardjiman ., Ni Nyoman Yuliarti, Sasmito ., Agung Endro Nugroho

Abstract


The study was designed to investigate whether 2-(4’-dimethylamino benzylidene)-6-benzylidene cyclohexanone (named code “B”) can be synthesized by reaction of Claissen–Schmidt condensation with 4'-dimethylamino benzal-dehyde, benzaldehyde, and cyclohexanone as starting materials and to evaluate its antioxidant and anti-inflammatory activities. The study showed that compound B at the concentration of 5, 10, 20, 40, and 80ppm did not exhibit antioxidant activity. In order to access the antiinflammatory activity, this compound was administered orally an hour before intra-plantar injection of carraagenan 1% on rat paw. Anti-inflammatory effect was evaluated by measuring the volume of edema every hour for 5h. Statistical analysis was performed by one way anova at 95% confidence level and followed by LSD test. “B” was potential as an anti-inflammatory agent at the dose of 132.40mg/200g BW by decreasing the volume of paw edema.
Key words: synthesis; 2-(4’-dimethylaminobenzylidene)-6-benzylidene cyclohexanone; antioxidant; anti-inflammatory

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References


Anonym, 2006, Antioxidant and Free Radical, (Online), (http ://www.chem-is-try.org) accessed 22th November 2006. Chattopadhyay P., Hazarika S., Dhiman S., Upadhyay A., Pandey A., Karmakar S., Singh L., 2012, Vitex negundo inhibits cyclooxygenase-2 inflammatory cytokinemediated inflammation on carrageenaninduced rat hind pawedema, Pharmacognosy Res., 4(3):134-137.

Majeed, M., Badmaev, V., Shivakumar, U., Rajendra, R., 1995, Curcuminoids: Antioxydant Phytonutrients, NutriScience Publisher Inc, Pitscataway, New Jersey, 32-63.

Nugroho AE., Ikawati Z., Sardjiman, Maeyama K., 2009, Effects of benzylidene cyclopentanone analogues of curcumin on histamine release from mast cells. Biol Pharm Bull. 32(5): 842-849.

Sardjiman, 2000, Synthesis of some New Series of Curcumin Analogues, Antioxidative, antiinflammatory, antibacterial activities and Qualitative Structure Activity Relationship, A Disertation, Department of Pharmaceutical, Gadjah Mada University, Yogyakarta.

Sun, You-Min, Zhang, Hong-Yu, Chen, De-Chan and Liu, CB., 2002, Theoritical Elucidation on the Antioxidant Mechanism of Curcumin: A DFT Study, Shandong University, Jinan.

Tonnesen, HH. and Greenhill, JV., 1992, Studies on Curcumin and Curcuminoid XXII: Curcumin as a Reducing Agent and as a Radical Scavenger, Int. J. Pharm., 87, 79-87.




DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp198-205

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