Optimization of chitosan and sodium carboxymethylcellulose as mucoadhesive system in theophylline tablet
Mucoadhesive tablet for asthma treatment were prepared by mixing theophylline with two variations of polymers. The purpose of this research was to controlled drug release from the dosage form. Theophylline mucoadhesive tablets were prepared by direct compression using chitosan and sodium carboxymethylcellulose as mucoadhesive polymers. Mucoadhesive strength measured using rabbit gastric mucosa and in vitro drug dissolution was subjected in a hydroclorid acid buffer pH 1.2 for 10 hours. The optimized formula was obtained by analyzing both evaluation using factorial design. Formula with 5.4 % of chitosan and 14.5 % of sodium carboxymethylcellulose followed zero order kinetics. The optimized formulation showed by 8.38-10.91% of chitosan and 28.84-29.09% of sodium carboxymethylcellulose with mucoadhesive strength between 25-40 gram and 43.5%-55% drug was released in 10 hours.
Key words: Mucoadhesive, chitosan, CMC Na, E, factorial design.
Bolton, S. 1997. Pharmaceutical Statistic Practical and Clinical Application, 3rd Ed, 326 – 353, 591 – 601. Marcel Dekker Inc, New York.
Deacon, M. P., Clive J. R., Phillip M. W., Saul J. B. T., Martyn C. D., S. S. (Bob) DAVIS and Stephen E. H 2000. Atomic Force Microscopy Of Gastric Mucin and Chitosan Mucoadhesive Systems. Biochem. J. (2000) 348, 557-563.
El-Kamel, A.H., Sokar, M.S., Naggar, V.F., and Gamal, S.A . 2002a. Bioadhesive Controlled Release Metronidazol Vaginal Tablets. Acta Pharm. 52 171-179.
El-Kamel, A.H., Sokar, M.S., Naggar, V.F., and Gamal, S.A. 2002b. Chitosan and Sodium AlginatBased Bioadhesive Vaginal Tablets. AAPS PharmSci2002; 4 (4) article 44.
Indrawati, T., Agoes, G., Yulinah ,E., and Cahyati,Y. 2005. Uji Daya Lekat Mukoadhesive Secara In Vitro Beberapa Eksipien Polimer Tunggal dan Kombinasinya pada Lambung dan Usus Tikus. Jurnal Matemetikan dan Sains, Vol 10 No. 2, hal 45-51.
Lachman and Liberman. 1994. Teori dan Praktek Farmasi Industri, terjemahan Edisi ketiga. Jakarta: Universitas Indonesia Press.
Jeon, J., 2007. Development and Formulation Of Carbomer 934P Containing Mucoadhesive Pellet By Fluid-Bed techniques. Elektronisches Dokument. urn:nbn:de:gbv:3-000012267.
Ogawa, K., Tadashi, U., and Satoru T. 1980. Theophylline Sustained Release Granule. United State Patent4261970. [27 September 2008].
Saifullah, T. N., Yandi, S., Utami, R. 2007. Profil pelepasan Propanolol HCl dari Tablet Lepas Lambat dengan Sistem Floating Menggunakan Matriks Methocel K15M. Majalah Farmasi Indonesia, 18(I), 48-55. September 2008].
Semalty, A., and Semalty, M. 2008. Mucoadhesive Polymers-A Review.
Singh, B., Chakkal, S. K., and Ahuja, N. 2006. Formulation and Optimization of Controlled Release Mucoadhesive Tablets of Atenolol Using Response Surface Methodology. AAPS PharmSciTech. 2006; 7(1): Article 3. DOI: 10.1208/pt070103.
The United States Pharmacopeia Convention, 2002. The Pharmacopeia Of The United States Of America 25th Revision. Washington D.C: The United States Pharmacopeia Convention Inc.
- There are currently no refbacks.
Copyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Indonesian J Pharm indexed by:View My Stats