Niosomes entrapment capacity of ketoprofen and prediction transdermal administration
Niosomes are vesicles system that have applications in the delivery of lipophilic,hydrophilic and amphiphilic drugs. Ketoprofen, is very insoluble in water and cause gastric irritation when taken orally. It is very important to develop a transdermal delivery system for ketoprofen. This research was aimed to design niosomes which can deliver ketoprofen via transdermal route. Experiments were designed to incorporate ketoprofen into niosomes with lipid film hydration method. Lipid mixture consist of cholesterol and sorbitan ester (span 20, 60, 80). Niosomes which can deliver ketoprofen trough the skin barrier determined by calculating amount of ketoprofen in the blood of rabbit. The type of sorbitan ester was chosen based on the highest drugs entrapment and ketoprofen as drugs model. Preparation of niosomes was optimized for the highest percent drug entrapment by increasing molar concentration of lipid
mixture with the stable comparison of 1:1. This research result are niosomes with lipid mixture span 60 and cholesterol have the highest drug entrapment efficiency of niosomes 66.16% with range size 1–6 µm. Niosomes can deliver ketoprofen to the systemic circulation via transdermal route with plasma level concentration achieved in 1.5 hour.
Key words: niosomes, ketoprofen, transdermal
Arora R. and Jain C.P. 2007 Advances in niosome as a Drug carrier, Asian Journal of Pharmaceutics, April-June , 1(1), 29 – 39.
Blazek-Welsh, A.I and D.G. Rhodes. (2001), Maltodextrin-based Proniosome, AAP Pharmaceutical Sciences, 3(1), 1 – 8.
Darnpanid 2004, The Effect of Phospholipid as Penetration Enhancer on Skin Permeation of Ketoprofen, Thesis,Mahidol University, Thailand.
Gregoriadis, G., 2007, Liposome Technology; Liposome Preparation and Related Techniques, Third Edition,Vol I,USA: Informa Healthcare USA Inc, pp. 21-32
Gregoriadis, G., 2007, Liposome Technology; Enttrapment of Drug and Others Material into Liposome , Third Edition,Vol II, USA: Informa Healthcare USAInc.
Gupta A., Prajapati S.K., Balamurugan M., Singh M., and Bhatia D., 2007, Design and Development of a Proniosomal Transdermal Drug Delivery System for Captopril, Topical J. of Pharmaceutical Research6(2), 687-693.
Jufri M., 2004, Arah dan Perkembangan Liposom DrugsDelivery System, Majalah Ilmu Kefarmasian, I(2), 59 – 68.
Kozubek A., Gubernator J., ,Przeworska E., and Stasiuk M., 2000 Liposomal drug delivery, a novel approach: PLARomes, Acta Biochimica Polonica,47(3), 639-649.
Manosroi A., Wongtrakul P., Manosroi J., Sakai H., Sugawara F., Yuasa M., and Abe M., 2003, Characterization of vesicles prepared with various non-ionic surfactan mixed with colesterol, Colloids and Surfaces B:Biointerfaces30, 129-138.
Patil P., Joshi P., and Paradkar A., 2004, Effect of Formulation Variables on Preparation and Evaluation of Gelled Self-emulsifying Drug DeliverySystem (SEDDS) of Ketoprofen, AAPS PharmSciTech;5 (3), 1-8
Patel P.A., Chaulang GM., Akolkotkar A., Mutha SS.,Hardikar SR and Bhosale AV., 2008 Self Emulsifying Drug Delivery System: A Review, Research J. Pharm. and Tech. Oct.-Dec. 1(4), 313 - 323
Rhee G., Ju W.J.S., Hwang,S.J., and Lee Y.W., 1999, Topical Oleo-Hydrogel Preparation of Ketoprofen with Enhanced Skin Permeability, Drug Dev. and Indust. pharm, 25(6),717 -726.
Reynolds J.E.P., 1993., Martindale The Extra Pharmacopoeia 28th ed., London : Pharmaceutical
Shahiwala A., and Misra A., 2002, Studies in topical application of niosomally entrapped Nimesulide, J Pharm Pharmaceutical Sciences, 5(3) 220-225.
Sumirtapura Y.C., Saungnage B., and Rachmat M., 2002, Farmakokinetik dan Ketersediaan Hayati Relatif Sediaan Kapsul,Tablet Salut Enterik dan Suppositoria Ketoprofen, Jurnal Matematika dan Sains,7(1),15-19.
Tatro D.S., 2003, A to Z Drug Facts, Book@Ovid, Electronic version
- There are currently no refbacks.
Copyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Indonesian J Pharm indexed by:View My Stats