Optimization of chitosan, sodium carboxy methyl celulose and magnesium stearat as mucoadhesive system in captopril tablet

Eka Deddy Irawan, Achmad Fudholi


Captopril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and some types of congestive heart failure. It has been reported that the duration of antihypertensive action after a single oral dose of captopril is only 6–8 h. Captopril is most stable at acidic condition and as the pH increases, it becomes unstable and undergoes a degradation reaction. These indicates a promising potential of the captopril mucoadhesive system as an alternative to the conventional dosage form. The objective of the current study was to find an optimum formula of mucoadhesive tablet for captopril using factorial design. Tablets were evaluated for mucoadhesive strength and drug release profile. The studies were perfomed to establish composition of chitosan, sodium CMC and Mg stearat. Such composition could produce mucoadhesive strength with a zero order release kinetics. A 23 factorial design has been applied to systematically optimize the formula. The amounts of chitosan (XA), sodium CMC (XB), and Mg stearat (XC) were selected as independent variables. Mucoadhesive strength and dissolution efficiency (DE480) were selected as dependent variables. According the contour plot suggested that optimum formula will be reach mucoadhesive strength (26-30 g) and DE480 (≥70 %) chitosan at low to middle level (20-35 mg), sodium CMC at middle to high level (150-200 mg), and Mg stearat at low to middle level (4-6 mg).

Key words : mucoadhesive, factorial design, DE480 , chitosan, CMC Na, Mg stearat, contour plot


Chandru, H., and Sharada A.C., 2007, Simple and Rapid Methods for the Analysis of Captopril in Dosage Forms, E-Journal of Chemistry, 4(2) pp 216-221.

Patel, V.M., Bhupendra G. Prajapati, Harsha V. Patel, and Karshanbhi M. Patel., 2007, Mucoadhesive Bilayer Tablets of Propanolol Hydrochloride, AAPS PharmSciTech, 8 (3) Article 77, E1-E6.

Patchett, A.A., Harris, E., and Tristam, E.Q., 1980, A New Class of Angiotensin-Converting Enzyme Inhibitors, Nature, 288(5788):280–3.

Ponchel, G., and Irache, J., 1998, Specific And Non-Specific Bioadhesive Particulate Systems for Oral Delivery to The Gastrointestinal tract. Adv Drug Deliv Rev, 34:191-219.

Rocca, J.G., Omidian, H., and Shah, K., 2003, Progress in Gastroretentive Drug Delivery Systems. Pharmatech Drug Delivery Oral. Bussiness Briefing Pharmatech, 152, Diterima 4 Januari 2007,dari http ://www.touchbriefings.com.

Singh, B., Chakkal, S.K., and Ahuja, N., 2006, Formulation and Optimatization of Controlled Release Mucoadhesive Tablets of Atenolol Using Response Surface Methodology, AAPS PharmSciTech., 7 (1) Article 3 , E1-E10.

Yang, L., Esharghi, J., and Fassihi, R., 1999, A New Intra Gastric Delivery System for The Treatment of Helicobacter pylori Associated Gastric Ulcers: in Vitro Evaluation, J. Control Release., 57:215-222.

DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp231-238


  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:

analytics View My Stats