The effect of fumaric acid-sodium bicarbonate on the green tea effervescent granule’s quality made by dry granulation

Agatha Busi susiati Lestari, Maria Yuli Trisusilawati

Abstract


Tea plant (Camellia  sinensis  L.)  had been  known  to  contains epigallocathecin gallate (EGCG) that can be used to maintain the healthy. In this research, the green tea was  tried to be formulated in effervescent dosage form, with  the  focus  on  the  effect  among  fumaric  acid,  sodium  bicarbonate,  and  the interaction  between  fumaric  acid  and  sodium  bicarbonate  on  the  green  tea extract  effervescent granule’s  physical properties, that made by dry granulation method.  Physical  properties  of  effervescent  granule  that  been  study  were moisture  content,  flow  rate,  disintegration  time,  and  pH  of  the  solution.  The result showed that sodium bicarbonate was dominant in determining pH, granule flow  rate  and  moisture  content  of  granule,  whereas  fumaric  acid  dominant  in disintegration time of effervescent granule.

Key words: green tea, fumaric acid, effervescent granule, dry granulation


Full Text:

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DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp218-224

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