Studi on the in vitro release of ibuprofen from xanthan gum matrix combined with a crosslinking agent
Ibuprofen is non-steroidal anti-inflammatory drugs that is often used so frequently in a day that is can cause the patient to forget to take it. Besides it may cause gastro intestinal disturbances, which increase with the frequent of use. Many studies have been undertaken to obtain ibuprofen controlled release systems. Based on this, this study is done to find out the in vitro release kinetic of ibuprofen from xanthan gum matrix combined with a crosslinking agent, that is locust bean gum or calcium sulphate.
In this research there were six formulas sustained release ibuprofen tablet that was made by the same compression pressure. Formula I, II and III used matrix combination of xanthan gum and locust bean gum (1:½, 1:1, 1:1½), while formula IV, V and VI used matrix combination of xanthan gum and calcium sulphate (1:½, 1:1, 1:1½). Afterward, the physical and release characteristics of the tablet were examined.
The results showed that the compactibility of matrix combination of xanthan gum and locust bean gum was different from the matrix combination of xanthan gum and calcium sulphate. Combination of xanthan gum and locust bean gum and also calcium sulphate as crosslinking agent can influence the physical properties and the release profile of tablet.
Key words: ibuprofen, xanthan gum, locust bean gum, calcium sulphate, dissolution, sustained release tablet.
Anonim, 1979, Farmakope Indonesia, ed.III, Departemen Kesehatan RI Jakarta, hal. 6-7.
Anonim, 1995, Farmakope Indonesia, ed. IV, Departemen Kesehatan RI, Jakarta, 6, 449-451, 1083-1086, 12 10.
Anonim, 2002, Information for Health Professionals: Brufen Retard, http://www.medsafe.govt.nz/profs/ Datasheet/b/brufenretardtab.htm. [2004, January 15]
Anonim,2005,Water Structure and Behavior : Xanthan Gum, http://www.sbu.ac.uk/water/ hyxan.html [2003, June 12]
Baichwal, A, R., 2001a, Sustained Release Matrix for High Dose Insoluble Drugs, US Patent 9,842,289.
Baichwal, A, R, 2001b, Sustained Release Heterodisperse Systems-amorphous Drugs, US Patent 9, 879, 296
Fudholi, A., 1983, Metodologi Formulasi Dalam Kompresi Direk, Medika, 9, 586-593.
Hwang, R.C., Peck, G.R., Besserman, D.M., Friedeich, C.E., and Gemoules, M.K., 2001, Tablet Relaxation and Physicomechanical Stability of Lactose, Microcrystalline Cellulose, and Dibasic Calcium Phosphate, Pharmaceutical Technology, November, 54-81.
Kurumaddali, K.R., Ravis, W.R., and Betageri, G.V., 1994, Preparation and Evaluation of Sustained Release Ibuprofen Beads, Drug Development and Industrial Pharmacy, 20(17), 2659-2669.
Lapidus, H, and Lordi, N. G., 1968, Drug release from Compressed Hydrophylic Matrices, J. Pharm. Sci., 57, pp. 1292-1301.
Park, K., Shalaby, W. S. W., and Park, H., 1993, Biodegradable Hydrogel s for Drug Delivery, Technomic Publishing Company Inc., Pensylvania, 72, 108-109.
Shehab, M. A., and Richards, J. H., 1996, Studies on the In Vitro Release of lbuprofen from Polyethylene Glycol-Polyvinyl Acetat Mixtures Liquid Filled into Hard Gelatin Capsules, Drug Development and Industrial Pharmacy, 22(7), 645-651.
Tehrani, M.R., and Shobeiri, N. S., 1995, Effect of Various Polymers on formulation of Controlled Release (CR) lbuprofen Tablets by Fluid Bed Technique, Drug Development and Industrial Pharmacy, 21 (10), 1193-1202.
Wagner, J.G., 1971, Biopharmaceutics and Relevant Pharmacokinetics, 1st Edition, Drug Intelligence Publication, Illionis, pp. 115-120.
Wise, D. L., 2000, Handbook of Pharmaceutical Controlled Release Technology, Marcel Dekker, Inc., Newyork, 83-209, 477.
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