Identification of physical interaction between levodopa–benzerazide hydrochloride

Ilma Nugrahani, Sukmadjaja Asyarie, Sundani Noerono Soewandhi, Slamet Ibrahim


The aim of this research was to investigate the possibility physical interaction occurred between of levodopa and benzerazide hydrochloride, which known as compounds used in combination for the the antiparkinson. The “cold contact methods” was used which was developed from Kofler contact method’s (hot stage methods). Thermograms Differential Scanning Calorimetry and difractograms X-Ray indicated that levodopa – benzerazide hydrochloride tent to form a peritecticum-molecular compound physical interaction with eutectics point at 4:6 and 9:1 molar ratios.

Key words: benzerazide hydrochloride, cold contact method, levodopa, physical interaction.

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Cartensen, J. T., 1980, Solid Pharmaceutics: Mechanical Properties and Rate Phenomena, Academic Press, New York, 102-108.

Chadha, R., Kashid, N., and Jain, D.V.S., 2004, Microcalorimetric evaluation of the in vitro compability of amoxicillin / clavulanic acid and ampicillin / sulbactam with ciprofloxacin, Journal of Pharmaceutical and Biomedical Analysis, 36 , 295-307.

Davis, R.E,, 2004, Studies Phase Relationships in Cocrystal Systems, American Crystallographic Association, ACA Transaction, 39, 41-61.

Departemen Kesehatan RI, 1995, Farmakope Indonesia IV, Depkes RI, Jakarta, 492-493.

McEvoy, G., 2002, AHFS Drug Information, America : American Society of Health System Pharmacist, Wisconsin, 2452.

Merdinasari, 2005, Interaksi Fisika Benserazid dan Levodopa, Skripsi, Departemen Farmasi, FMIPA, ITB, Bandung.

Nugrahani, I., Asyarie, S., dan Soewandhi S. N., 2006, Metode Kontak Dingin untuk Mendeteksi Interaksi Fisika Sistem Dua Komponen : Pseudoefedrin hidroklorida dan Antalgin – Fenilbutason (I), Penelitian Disertasi, Sekolah Farmasi ITB, Bandung.

Nugrahani, I, Soewandhi S. N., Asyarie, S., dan Suyono, M., 2006, Konfirmasi Metode Kontak Dingin dengan DSC dan XRD untuk Menentukan Jenis Interaksi Fisika Sistem Dua Komponen : Pseudoefedrin hidroklorida dan Antalgin – Fenilbutason (II), Penelitian Disertasi, Sekolah Farmasi ITB, Bandung.

Sweetman, S.C., ed., 2002, Martindale, The Complete Drug Reference, 33 ed., Pharmaceutical Press, London, 1164.

Soewandhi, S.N., 2005, Kristalografi 1 dan 2Sekolah Farmasi ITB, Bandung,.

Swarbrick, J. and Boylan, J.C. (Ed.), 1994, Encyclopedia of Pharmaceutical Technology, Vol.3: Crystallization and the Properties of Crystals, Marcel Dekker Inc, New York & Basel, 399- 434.

Idem, Encyclopedia of Pharmaceutical Technology, 1994,: Liquid Oral Preparation, Marcel Dekker Inc, New York and Basel, Vol.9 : 42-45. The Department of Health Great Britain, 2003, British Pharmacopoeia, The Stationery Office, London, 196, 1091.

Willard, H.H., L.L., Merit J.A. Dean, and F.A. Settle, 1988, Instrumental Methods of Analysis, Wadsworth Pub. Co., Belmont, 761-764.

Wijaya, H.M., 2003, Identifikasi Jenis Interaksi Fisika antara Trimetoprim dengan Sulfometoksazol Menggunakan Metode Analisis Termal, Skripsi, Departemen Farmasi, FMIPA, ITB, Bandung.



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