Influence of administration of gadung corm ((Dioscorea hispida Dennst) infusion to decrease of blood glucose level at aloksan inducted male diabetic rats.

Endang Sri Sunarsih; Djatmika .; Retno Sri Utomo

doi:10.14499/indonesianjpharm0iss0pp29-33

Influence of administration of gadung corm ((Dioscorea hispida Dennst) infusion to decrease of blood glucose level at aloksan inducted male diabetic rats.

Endang Sri Sunarsih, Djatmika ., Retno Sri Utomo

Abstract

Traditional herba medicine, Gadung (Dioscorea hispida Dennst) has already known can be used for oral anti diabetic drug. But it have not be proved experimentally. The purpose of experiment want to know the influence of Gadung (Dioscorea hispida Dennst) corm infuse, can decrease blood glucose consentration diabetic aloxan inducted rats.

This experiment use 20 rats by randomized design at 2-3 months, 140-280 gram BW, Aloxan inducted diabetic male albino Wistar strain. The dose of aloxan 150 mg/BW given by intraperitonial. The rats divided in 4 groups, each group consist of 5 rats. First group : positif controle which is given insulin 12,6 UI/BW subcutanly; Second group : negative controle which is given aqua dest 5 mL/BW orally; Third group is given Gadung (Dioscorea hispida Dennst) corm infuse 630 mg/BW orally and Forth group is given Gadung (Dioscorea hispida Dennst ) corm infuse 1260 mg/BW dose orally. The experiment results of blood glucose level, was analyzed by 2 way ANOVA (p<0,05).

The conclusion of the experiment is the rats has given Gadung (Dioscorea hispida Dennst) corm infuse 630 mg/BW and 1260 mg/BW can decrease blood glucose consentration proporsionally with insulin effect (p<0,05).

Key words : Gadung (Dioscorea hispida Dennst), Aloksan, antidiabetic drug.

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DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp29-33