Effect of Stenochlaena palustris extract on circulating endothelial cellsMarmota caligata induced fever

Eko Suhartono, M. Bakhriansyah, Rini Handayani


Fever is increased  temperature  regulation  of  the  body.  In  the  process  is according  indirect  which  increased  of  free  radicals,  as  anion  superoxide  (•O2) and  will  trigger  oxidative  stress  happened.  Oxidative stress will effect in endothelial damaged. A celluler marker of damage the endothelium is increased number of Circulating  Endothelial  Cells (CEC).  The  aim  of  this  research  is  to valuated the influence of watery plant kalakai extract (Stenochlaena palustris)to number  of  Circulating  Endothelial  Cells  in  Marmota  caligata had  been  fever  and to calculated the average of CEC. The research is true experimental study, with Posttest-Only with Control Group Design, with 2 control group and 5 treatments group  of  each  4  Marmota  caligata. The CEC is   measured  by  Hladovec  method. Data  was  analyzed  by  using  Kruskal-Wallis  test  with confidence  rate  at  95  %. The  analyzed  results  got  p  =  0.001  (p  <  0.05)  means there  be  a  significant different  between  treatment  group.  From the  result, can  be  conclude  that  the present of watery  plant kalakai  extract is decreasing CEC in plasma of Marmota caligatafever induced.

Key words: Fever, Circulating Endothelial Cells, Stenochlaena palustris

Full Text:

PDF 166-170


Boos, C. J., Lip, G. Y. H., and Blann, A. D., 2006,Circulating endothelial cells in cardiovascular disease, J Am Coll Cardio, 48, 1538-47.

Byrne, D. J. O., Devaraj. S., Grundy, S. M., and Jialal I., 2002, Comparison of the antioxidant effects of concord grape juice flavonoids and α-tocopherol on markers of oxidative stress in healthy adults, Am J Clin Nutr, 76, 1367–74.

Catharina, 2001, Pathogenesis of dengue hemorrhagic fever and denguesyok syndrome in: dengue hemorrhagic fever

in Indonesia: the role of cytokines in plasma leakage, coagulation, and fibrinolysis. Nijmegen University Press, 15-23.

Gunawan, S. G., Setiabudy, R., Nafrialdi, and Elysabeth, 2007, Farmakologi dan terapi, edisi 5, FKUI, Jakarta

Haubitz, M., and Woywodt, A., 2004, Circulating endothelial cells and vasculitis, J Int Med, 43, 660-7.

Hladovec, B., and Rossman, P., 1973, Circulating endothel cell isolated together with platelet and experimental modification of their counts in rats, Pergamon Press Inc, 665-7

Maharani, Haidah, and Hainiyah, 2006, Studi potensikalakai sebagai pangan fungsional. Kumpulan Makalah PIMNAS XIX, 26-29 Juli di Universitas Muhamadiyah Malang.

Pribadi, M. J., Makmun, L. H., and Abdurahman, N., 2000, Disfungsi endotel dan aterosklerosis koroner, Acta Medica Indonesiana, 32(2),67-79.

Sudjarwo, S. A., 2006, The potency of piperine as antiinflammatory and analgesic in rats and mice, Folia medica Indonesiana, 41(3),190-4.

Suhartono E, 2008, Potention of aquaeus extract kalakai as antiinflammation by oxidative mechanism, Congress International Korean Medicine, Sangji University Korea, 22-23 October.

DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp166-170


  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:

analytics View My Stats