The effect of pretreatment of Broccoli (Brassica oleracea L. var. botrytis L.)  to rifampicin pharmacokinetics in rats

Djoko Wahyono; Arief Rahman Hakim

doi:10.14499/indonesianjpharm0iss0pp177-181

The effect of pretreatment of Broccoli (Brassica oleracea L. var. botrytis L.) to rifampicin pharmacokinetics in rats

Djoko Wahyono, Arief Rahman Hakim

Abstract

Consuming the meal during drug therapy could influence on pharmacokinetics profile of the drugs. The research was aimed to observe broccoli (Brassica oleracea L. var. botrytis L.) activities to rifampicin pharmacokinetics in rats.
The study of interaction broccoli with rifampicin pharmacokinetics was conducted employing a completely randomaized design using female Sprague Dawley rats which were divided into 3 groups (6 rats for each group).
The results have shown that the pharmacokinetics values of rifampicin in the animals prefed with broccoli 23.43 mg/kg BW 1 hours prior to single oral administration of the drug (P-II) did not change significantly (P>0.10). Prefeeding the animals with broccoli 23.43 g/kg BW once daily for 7
consecutive days (P-I) has increased the total clearance of rifampicin 46.90% (P<0.10). The increase in the total clearance rifampicin due to the compound has decreased Cmaks 36.54% (P<0.10).
Key words : broccoli, rifampicin, pharmacokinetics

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References

Brown, J.E., dan Shand, D.G., 1982, Therapeutic drug monitoring of antiarrythmic agents, Clinical Pharmacokinetics, 7 : 125-148.

Dollery, S.C., 1991, Therapeutic drugs, vol. 2, T32-T40, Churchill Livingstone, Edinburg.

Follath, F., Ganzinger, U., dan Schuetz, E., 1983, Reliability of antiarrhytmic drug plasma concentration monitoring, Clinical Pharmacokinetics, 8 : 63-82.

Gibson, G.G., dan Skett, P., 1986, Introduction to drug metabolism, Chapman and Hall, London.

Johnston, A. and Woollard, R.C., 1983, STRIPE: A computer program for pharmacokinetics, J. of Pharmacol.Methods, 9: 193-199.

Jung, D.T., 1984, Stripe, College of Pharmacy University of Illinois, Chicago. Laboratorium Farmakologi dan Toksikologi Fakultas Farmasi UGM, 2003, Uji bioekivalensi tablet FDC RHE (150/75/275) (PT Indofarma Tbk) terhadap tablet Rimactane 450 mg (PT Novartis Biochemie) pada sukarelawan sehat, Laporan Penelitian, Fakultas

Farmasi Universitas Gadjah Mada, Yogyakarta.

Liener, I.E., 1969, Toxic Constituens of plans foodstuff, Academic Press, New York.

Mandell, G.L. and Petri, W.A., 1996, Antimicrobial Agent (Continued), In Goodman Gilman (Ed.),

Ed., 1487-1511, McGraw-Hill International Editions, Singapore. The Pharmacological Basic of Therapeutics, 9th

Mutschler, E., 1986, Dinamika obat, diterjemahkan oleh Widiyanto, M.B., dan Ranti, A.S., edisi ke-5, ITB, Bandung

Noordhoek, J., dan van Bladeren, P.J., 1991, Nutrition and extrahepatic metabolism, in : Rowland,I.R., (ed), Nutrition, toxicity, and Cancer, CRC Press Inc., Boca Raton, Florida

Ratti, B., dan Parenti, R., 1981, Quantitative assay of rifampicin and its main metabolite 25desacetyl rifampicin in human plasma, Journal of Chromatography, 225: 526-531

Sari, I.P., 1999, Antaraksi farmakokinetika brokoli (Brassica oleracea L. var. botrytis L.)–kinidin, kajian terhadap akibat dan perantara antaraksi, Tesis, Program Studi Ilmu Farmasi, Jurusan Ilmu-Ilmu Matematika dan Pengetahuan Alam, Program Pascasarjana, UGM, Yogyakarta.

Shargel, L. and Yu, A.B.C., 1994, Applied biopharmaceutics and pharmacokinetics, 4ed., McGraww-Hill Medical Publishing Division, New York.

Watson, D.H., 1987, Natural toxicant food, Ellis Horwood Ltd., Chichester.

DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp177-181