Antiurolitihatic potency of Ketimun juice (Cucumis sativus L.) on white male rats using Kalkuli method

Sumi WIjaya, Farida L Darsono

Abstract


The aim of this research was to know the antiurolitihatic activities of Ketimun juice (Cucumis sativus L.) on white male rats which have been induced with hydroxyproline 30 % with a dose of 2,5 g/Kg BW. The 20% Ketimun juice (1.5 ml/100 g BW) and distilled water 1.5 ml/100 g BW were given the test animals orally.
The parameter tests were characteristics of the kidney : the colour, shape, size and ratio of kidney weight /200 g BW and 24 hour urine on the first and the third days which included pH, 24 hour urine volumes and the calcium content in the urine.
The data were analyzed using one sampel t-test. There were significant differences (p<0,05) between control and the treatment groups The significant differences were that Ketimun juice can reduce the calcium content on the urine, pH urine and the ratio of kidney weight /200 g BW and
increase the volume of the 24 hours urine.
Key Words : ketimun, antiurolithiatic, hydroxyproline, cucumis sativus L.

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DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp173-176

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