Antiurolitihatic potency of Ketimun juice (Cucumis sativus L.) on white male rats using Kalkuli method

Sumi WIjaya, Farida L Darsono


The aim of this research was to know the antiurolitihatic activities of Ketimun juice (Cucumis sativus L.) on white male rats which have been induced with hydroxyproline 30 % with a dose of 2,5 g/Kg BW. The 20% Ketimun juice (1.5 ml/100 g BW) and distilled water 1.5 ml/100 g BW were given the test animals orally.
The parameter tests were characteristics of the kidney : the colour, shape, size and ratio of kidney weight /200 g BW and 24 hour urine on the first and the third days which included pH, 24 hour urine volumes and the calcium content in the urine.
The data were analyzed using one sampel t-test. There were significant differences (p<0,05) between control and the treatment groups The significant differences were that Ketimun juice can reduce the calcium content on the urine, pH urine and the ratio of kidney weight /200 g BW and
increase the volume of the 24 hours urine.
Key Words : ketimun, antiurolithiatic, hydroxyproline, cucumis sativus L.

Full Text:



Araujo. T, dkk, 1988, Evaluation of The Antiurolithiatic activity of The Extract of Costus spiralis Roscoe in Rats, Journal of Ethnopharmacology Vol 43.

Anonim, 1993, Penapisan Farmakologi, Pengujian Fitokimia dan Pengujian Klinik, Jakarta: Yayasan Pengembangan Obat Bahan Alam Phyto Medica

Debora L., dkk. 1997. Pengaruh Infus Daun Sonchus arvensis terhadap kadar kalsium darah urine yang

diekskresi pada tikus putih. Fakultas Farmasi Unika Widya Mandala Surabaya.

Sofowara and Abayomi, 1982, Medicinal Plants and Tradisional Medicine in Africa, New York, Jon Wiley

and Sons Limited Chichestern.

Surjoseputro S., 1977, Sonchus arvensis L. Sebagai Anticalculus Urinariae, Fakultas Farmasi Unika Widya

Mandala Surabaya



  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:

analytics View My Stats