Formulation of repellant gel of vetiver oil : Composition of carbopol 3% w/v – propilenglicol optimization
Firstly, vetiver oil was collected from dried root of Vetivera zizoioides (L) Nogh by water steam destilation. The obtained oil then was gelled by the aid of Carbopol 3% w/v solution – propilenglikol at various compositions. Factorial design method was employed to create the optimum composition of Carbopol 3% w/v solution – propilenglikol and was used to determined the effect of Carbopol 3% w/v solution – propilenglikol and their interaction on the gel characteristics.
The result showed that the effect of Carbopol 3% w/v solution was the dominant factor in the viscosity and repellant potency. While the effect of propilenglikol was the dominant factor in alteration of gel viscosity. The interaction between Carbopol 3% w/v solution and propilenglikol was dominant factor in spreadability. The optimum composition was created in superimposed countour plot. Irritation skin test on rabbit confirmed that all evaluated formulas were non irritating
Key words: formulation, repellant gel, vetiver oil
Anonim, 1994, The Pharmacceutical Codex, 12 thed, 82 – 92, The Pharmaceutical Press, London
Amstrong, N.A., James, K.C., 1996, Pharmaceutical Experimental Design and Interpretation, 131 – 165, Taylor and Francis, USA
Anggoro, A. B., 2003, Daya Repelan dan Daya Iritasi Minyak Atsiri Akar Wangi (Vetivera zizoniodes (L) Nogh) terhadap Nyamuk Aedes Albopictus, Skripsi, Fakultas Farmasi, Universitas Sanata Dharma Yogyakarta
Barry, B. W., 1983, Dermatological Formulation, 300-304, Mercel Dekker inc., New York
Boltons, 1997, Pharmaceutical Statistic Practical and Clinical Application, 3 rd ed, 326 – 353, 591 – 601, Marcel Dekker Inc, New York.
Coleman, R.E., Robert, L.L., Roberts, L.W., Glass, J.A., Seeley, D.C., Laughinghouse, A., Perkins, P.V., Wirtz, R.A., 1993, Laboratory evaluation of repellents against four anopheline mosquitoes (Diptera: Culicidae) and two phlebotomine sand flies (Diptera: Psychodidae), J Med Entomol, 30: 499 – 502, 1993
Edwards, D.L., Johnsons, C.E., 1987, Insect-repellent-induced toxic encephalopathy in child, Clin. Pharm, 6: 496 – 498, 1987
Garg, A., Aggarwal, D., Garg, S., and Sigla, A.K., 2002, Spreading of Semisolid Formulation: An Update, Pharmaceutical Tecnology, September 2002, 84- 102, www.pharmtech.com
Guenther, E., 1990, Minyak Atsiri, diterjemahkan oleh S. Ketaren dan R. Mulyono, J., Jilid III, Penerbit Universitas Indonesia, Jakarta
Qiu, H., Jun, H.W., McCall, J.W., 1998, Pharmacokinetics, formulations, and safety of insect repellent N.N.-diethyl-3-methylbenzamide (deet) : A review, J. Am. Mosq. Contr. Assoc, 14 : 12 – 27, 1998.
Robbins, P.J., Cherniack, M.G., 1986, Review of biodistribution and toxicology of the insect repellent N.N.-diethyl-3-methylbenzamide (deet), J. Toxicol. Environt, Hlth, 18: 503 – 525, 1986
Sudarto, 1989, Entomologi Kedokteran, 96 – 105, EGC, Jakarta
Tawatsin, A., Wratten, S.D., Scott, R.R., Thavara, U., Techadamrongsin, Y., 2001, Repellency of volatile oils from plants against three mosquito vectors, J Vector Ecol, 26 (1): 76 – 82, 2001.
Walker, T.W., Robert, L.L., Copeland, R.A., Githeko, A.K., Wirtz, R.A., Githure, J.I., Klein, T.A., 1996, Field evaluation of arthropod repellents, deet and a piperidine compound, AI3 – 37220, against Anopheles funestus and Anopheles arabiensis in West Kenya, J. Am. Mosq. Contr. Assoc, 12: 172 – 176, 1996
Yap, H.H., Jahangir, K., Chong, A.S.C., Adanan, C.R., Chong, N.L., Malik, Y.A., Rohaizat, B., 1998, Field efficacy of a new repellent, KBR 3023, against Aedes albopictus (Skuse) and Culex quinquefasciatus (Say) in a tropical environment, J Vector Ecol, 23: 62 – 68, 1998
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