The influence of lactose and povidon on the formulation of tablet containing Kaempferia galanga L . extract by a wet granulation method

Rina Kuswahyuning, Sri Sulihtyowati Soebagyo


Increasing use of Kaempferia galanga L. (Kencur) as a traditional medicine needs the development of more practical dosage form e.g. tablets. This study was conducted to observe the infuence of lactose as a filler and Povidon as a binding agent to the physical properties of the granules and to determine the optimum tablet formula for Kaempferia galanga L. extract by a wet granulation method.
The use of factorial design with 2 factors (lactose and Povidon) and 2 levels (lactose : low level = 300% and high level = 450% of the extract weight, respectively; Povidon : low level = 0.3% and high level = 3% of the extract weight, respectively), it needed four formulas to produce granules of the Kaempferia galanga L. extract. Each of the granules of Kaempferia galanga L. extract was produced by a wet granulation method and was dried at 40-60°C for 24 hours. Dry granules were tested on their properties of flowability, compactibillity and water uptake.
 Lactose significantly influenced the compactibillity and the water uptake, whereas Povidon significantly influenced the compactibillity, flowability and water uptake. Based on the contour plots of the physical properties of the granules and total responses, formula using 315% lactose and 2.98% Povidon of the extract weight, respectively, was chosen as the optimum tablet formula. Produced tablets had dark brown colour and weight uniformity with average weight of 373.60 ± 0.63 mg, hardness of 2.18 ± 0.192 kg, friability of 0.10 ± 0.011%, and disintegration time of 4.43 ± 0.147 minutes.
Key words : Kaempferia galanga L. extract, tablet formula, lactose, Povidon

Full Text:



Aliadi, A., Sudibyo, B., Hargono, D., Farouq, Sidik, Sutaryadi, dan Pramono, S., 1996, Tanaman Obat Pilihan, Yayasan Sidowayah, Jakarta, 139-141

Anonim, 1979, Farmakope Indonesia, Edisi III, Departemen Kesehatan RI, Jakarta, 6-7; 28

Anonim, 1986, Handbook of Pharmaceutical Excipients, American Pharmaceutical Association and the Pharmaceutical Society of Great Britain, Washington, London, 234-239

Armstrong, N. A., 1994, Tableting, in Pharmaceutics the Science of Dosage Form Design (Aulton, M.E., Ed), ELBS, Hong Kong, 647-668

Bolhuis, G.K. and Chowhan, Z.T., 1996, Materials for Direct Compaction, in Pharmaceutical Powder Compaction Technology (Alderborn, G. and Nystrom, C., Eds), Marcel Dekker, New York and Basel, 419-500

Bolton, S., 1997, Pharmaceutical Statistics, Practical and Clinical Applications, 3rd Ed., Marcel Dekker Inc, New York, 326-354; 590-625

Parrott, E.L., 1971, Pharmaceutical Technology Fundamental Pharmaceutics, 3rd Ed., Burgess Publishing Co., Minneapolis, USA, 73-84; 158-171

Rudnic, E.M. and Kottke, M.K., 1996, Tablet Dosage Forms, in Modern Pharmaceutics (Banker, G.S. and Rhodes, C.T., Eds), 3rd Ed., Marcel Dekker, New York, Basel, Hong Kong, 333-394

Summers, M.P., 1994, Granulation, in Pharmaceutics the Science of Dosage Form Design (Aulton, M.E., Ed), ELBS, Hong Kong, 616-627.



  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:

analytics View My Stats