Pharmacokinetics profile of pentagamavunon-0 after potassium pentagamavunonat-0 oral administration in rats
Potassium PGV-0 was a salt form of PGV-0 which has been developed to be a new medicine. The salt form was relatively water soluble and therefore was is expected to have better bioavailability and efficacy than the parent compound.
The research aims were to investigate the pharmacokinetics profiles of PGV-0 after the administration of its potassium salt per orally in male rats Wistar The treadment was done by using a completely randomized design to explore the profiles of PGV-0 in blood, its distribution into primary organs : liver, kidneys, lungs and small intestine, and also its elimination into urine and feces in the animals. Potassium PGV-0 was given single doses per orally at 40 and 80 mg/kg BW. The analytical assay for PGV-0 was conducted by an HPLC method with a UV-Vis detector.
The results shown that according to per oral administration of K-PGV-0 to the rats, there was no PGV-0 found in the blood monitored up to 360 minutes. The compound was not found in the liver nor kidneys, and only traces (<5% of dose) were found in the lungs or small intestine. Traces amounts of PGV-0 were also found in urine or feces. The extremely rapid disappearance of the compound from the blood may not be due to its rapid distribution into the organs but more likely due to its fast biotransformation in the blood or in the liver. This assumption is also supported by the facts that PGV-0 found in the urine or feces was negligible (< 5% of administered dose).
Key words : potassium pentagamavunon-0, pentagamavunon-0, pharmacokinetics
Amalia, E., 2001, Profil Kadar Senyawa 2,5-Bis-(4’-hidroksi-3’-metoksi benzilidin) Siklopentanon dalam Darah setelah Pemberian secara Oral pada Tikus Jantan SD, Skripsi, Fakultas Farmasi UGM, Jogjakarta.
Arief R. H., Lukman H., and Supardjan A.M., 2003, Pengaruh Pentagamavunon-0 Terhadap Farmakokinetika Teofilin Pada Tikus, Majalah Farmasi Indonesia, 14 (1), 244 – 249.
Ghatak, N. and Basu, N., 1972, Sodium Curcuminate as an effective Antiinflamatory Agent, Chemical Abstract, 77, 122263y.
Hadijah, S., 2003, Uji Daya Antiinflamasi Kronis Kalium Pentagamavunonat-0 (K PGV-0) pada Tikus Putih Jantan Galur SD secara Oral, Skripsi, Fakultas Farmasi UGM, Jogjakarta. Holder, G.M., Plummer, J.L., and Ryan, A.J., 1978, The Metabolism and Excreton of Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in rats, Xenobiotica, 8 (12): 761-768.
Huang, M.T., Ma, W., Lou, Y.R., Chang, R., Newmark, H., and Conney, A.H., 1995, Inhibitory Effect Curcumin on Tumorigenesis in mice, in Pramono S. (Ed.), Recent Development in Curcumin Pharmacochemistry, Proceeding of The International Symposium on Curcumin Pharmacochemistry (ISCP), August 29-31, 1995, Jogjakarta.
Johnson, A. and Woollard, R.C., 1983, STRIPE: A computer program for pharmacokinetics, J. of Pharmacol. Methods, 9: 193-199.
Jung, D.T., 1984, Stripe, College of Pharmacy University of Illinois, Chicago.
Kustaniah, 2001, Profil Kadar Senyawa 2,5-Bis-(4’-hidroksi-3’-metoksi benzilidin) Siklopentanon dalam Darah setelah Pemberian secara Oral pada Tikus Betina SD, Skripsi, Fakultas Farmasi UGM, Jogjakarta.
Majeed, M., Badmaev, V., Shivakumar, V., and Rajendra, 1995, Curcuminoids Antioxidant Photonutrients, Nutriscience Publisher, Piscataway, New Jersey, 1-78.
Martin, A., 1993, Farmasi Fisik : Dasar-Dasar Kimia Fisika dalam Ilmu Farmasetik, Ed. III, UI Press, Jakarta.
MOLNAS, 2001, Laporan Penelitian Farmakokinetika PGV-0 Setelah Pemberian Injeksi Intravena, Peroral dan Intraperitoneal Pada Tikus Jantan dan Betina, Proyek MOLNAS I, Kerjasama PT Indofarma dan PT Kalbe Farma dengan Fakultas Farmasi UGM, Buku IV, Jogjakarta
Mukhopadhyay, A., Basu, N., Ghatak, N., and Gujral, P.K., 1982, Antiinflamatory and Irritant Activities at Curcumin Analogues in Rats, Agent and Action, 12, 508-515.
Pan, M., Huang, T., and Lin, J., 1999, Biotransformation of Curcumin Through Reduction and Glucuronidation in Mice, Drug Metab. Dispos., 27 (1): 486-494.
Rahmatika, R., Uji Daya Antiinflamasi Akut Kalium Pentagamavunonat-0 (K PGV-0) pada Tikus Putih Jantan Galur SD secara Intravena, Skripsi, Fakultas Farmasi UGM, Jogjakarta.
Ravindranath, V., and Chandrasekhara, N., 1980, Absorption and tissue distribution of curcumin in rats, Toxicol., 16 : 259-265.
Ravindranath, V., and Chandrasekhara, N., 1981, In vitro Studies on The Intestinal Absorption of curcumin in rats, Toxicol., 20 : 251-255.
Ravindranath, V., and Chandrasekhara, N., 1982, Metabolism of curcumin: Studies with [3H] Curcumin, Toxicol., 22: 337- 344
Reid, E., 1978, Assay of Drugs and Other Trace Compound in Biological Fluids, North Holland Publishing Company, New York.
Sardjiman, 2000, Synthesis of Some New Series of Curcumin Analogues, Antioxydative, Antiinflammatory, Antibacterial Activities, and Qualitative – Structure Activity Relationships, Dissertation, Gadjah Mada University, Yogyakarta.
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