Structure and cytotoxic activity relationship of curcumin derivatives on Myeloma cells
Abstract
synthesized and evaluated for the activity on myeloma cell lines with direct counting method. The IC50 values for curcumin, 4-methyl, 4-ethyl, 4-propyl, 4-isopropyl,4-benzyl, 4-phenyl dan 4-paramethylphenylcurcumin are 8.78, 3.45, 2.93, 2.18, 4.20, 3.87, >100, >100 μM respectively. Its seem that the activity of the curcumin derivatives is corelated to the stabilization of β diketone moiety and positive partial charge of those compound.
Key words: Curcumin, myeloma cells, Curcumin derivatives
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DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp100-104
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