Structure and cytotoxic activity relationship of curcumin derivatives on Myeloma cells

Supardjan Amir Margono, Muhammad Da’i


Curcumin is a compound having broad spectrum of biological activities for example as anti-cancer. The aim of this research is to evaluate the relationship of structure and the cytotoxicity effect of curcumin and its derivatives on myeloma cell line. Some alkyl curcumin derivatives have been
synthesized and evaluated for the activity on myeloma cell lines with direct counting method. The IC50 values for curcumin, 4-methyl, 4-ethyl, 4-propyl, 4-isopropyl,4-benzyl, 4-phenyl dan 4-paramethylphenylcurcumin are 8.78, 3.45, 2.93, 2.18, 4.20, 3.87, >100, >100 μM respectively. Its seem that the activity of the curcumin derivatives is corelated to the stabilization of β diketone moiety and positive partial charge of those compound.
Key words: Curcumin, myeloma cells, Curcumin derivatives

Full Text:



Aggarawal, BB., Kumar, A. Aggarawal, MS., and Shishodia, S., 2003, Curcumin derived from Turmeric (Curcuma longa): A Spice for All Seasons, Phytochemical in cancer chemoprevention, 8(28), 1-9

Bharti, A.C., Donato, N.,, Singh, S., and Aggarawal, B.B., 2003, Curcumin (diferloymethane) downregulates the constitutive action of nyclear factor-κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis, Blood, 101(3), 1053-1062.

Brennan, P. and O’Neill, Luke A.J., 1998, Inhibition of Nuclear Factor B by Direct Modification in Whole Cells—Mechanism of Action of Nordihydroguaiaritic Acid, Curcumin and Thiol Modifiers, 55(7),965-973

Freshney, R.I., 1986, Culture of Animal cell a Practical Approach, 2nd ed., 71-73, IRL Press Ltd., Oxford.

Istiyastono, E.P., Supardjan, A.M., dan Pramono, H.D., 2003, Tautomeri Keto-Enol Kurkumin dan Beberapa Turunan Kurkumin Tersubstitusi Pada C-4, Suatu Kajian Pendekatan Kimia Komputasi, Majalah Farmasi Indonesia 14(3):107-133

Kawamori, T., Lubet, R., Steele, V.E., Kellof, G.J., Kakey, R.B., Rao., C.V., and Reddy, B.S., 1999, Chemopreventive Effect of Curcumin, a Naturally Occuring Anti-Infalammatory Prevent, during the Promotion/Progession Stages of Colon Cancer, CancerRes., 59, 567-601.

Majeed, M., Badmaev, V., Shirakumar U., and Rajendran, R., 1995, Curcuminoids antioxidant phytonutrients, 3-80, NutriScience Publisher Inc., PisCataway, New Jersey.

Meiyanto, E., 1999, Kurkumin Sebagai Obat Anti Kanker: Menelusuri Mekanisme Aksinya, Majalah Farmasi Indonesia, 10(4), 224-236.

Moos, PJ., Edes, K., Mullally, J.E., and Fitzpatrick, FA., 2004, Curcumin impairs tumor suppressor p53 function in colon cancer cells, Carcinogenesis, 25(9), 1611-1617

Pabon, H.J.J., 1964, A Synthesis of curcumin and related compounds, Recl. Trav. Chem., 23, 379-386.

Supardjan, A.M., 1999, Synthesis And Anti-Inflammatory Activity of Some 4-Substituted Curcumin Derivatives, Disertation, Gadjah Mada University

Snell, K., and Mullock, B., 1987, Biochemical Toxicology a Practical Approach, IRL Press Oxford, 57-59

van der Goot H, 1997, The chemistry and qualitative structure-activity relationships of curcumin, in Recent Development in Curcumin Pharmacochemistry, Procedings of The Internastional Symposium on Curcumin Pharmacochemistry (ISCP), August 29-31, 1995, edited by Suwijyo Pramono, Aditya Media, Yogyakarta Indonesia.

Singh, S. and Aggarwal, BB., 1995, Activation of transcription factor NF-κB is suppresed by curcumin (diferuloylmethane). J. Bio. Chem., 270, 24995-25000



  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:

analytics View My Stats