Synthesis of 4-phenyl-3,4-tetrahydro-indeno [2,1]-pyrimidin-2-one (LR-1)

Ritmaleni Ritmaleni; Wahyu Nurcahyani

doi:10.14499/indonesianjpharm0iss0pp149-155

Synthesis of 4-phenyl-3,4-tetrahydro-indeno [2,1]-pyrimidin-2-one (LR-1)

Ritmaleni Ritmaleni, Wahyu Nurcahyani

Abstract

The synthetic compound 4-phenyl-3,4-tetrahydro-indeno[2,1]- pyrimidin-2-one 20a (LR-1) was synthesised using Biginelli reaction method. The reaction involved benzaldehyde 6, 2-indanone 2 and urea 7 in acid condition. This condensation reaction yielded 15 % of the product 20, at 133,4-135,0^oC of melting point and 0.15 (Et2O : CHCl3 = 1 : 3) of R_f value.

Keywords : benzaldehyde, indenone-2, urea

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References

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DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp149-155