THE EFFECT OF REPEATED COMPACTION ON STARCH 1500 AS A FILLER-BINDER OF DIRECT COMPRESSION TABLET

Sri Sulihtyowati Soebagyo; Muliyadi .

doi:10.14499/indonesianjpharm0iss0pp166-171

THE EFFECT OF REPEATED COMPACTION ON STARCH 1500 AS A FILLER-BINDER OF DIRECT COMPRESSION TABLET

Sri Sulihtyowati Soebagyo, Muliyadi .

Abstract

Poor flowability is the weakness of Starch 1500 as a filler-binder of direct compression tablet. Granulation by compaction is one of the ways to improve the flow ability as it produced larger granules. Compaction of Starch 1500 (once) produced granules having flowability, compressibility and compactibility better than the original Starch 1500 powder. These granules, eventually, yielded tablets having higher hardness, less friable and longer disintegration time than that of the original Starch 1500. On twice compaction of Starch 1500, however, produced more fluid granules than previous method but the compressibility and compactibility tended to decrease. These type of granules yielded tablets having lower hardness and friability but higher disintegration time, significantly.

Key words: Starch 1500, granule, flowability, compressibility, tablet properties

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References

Alderborn, G. dan Nystrom, C., (Ed.), 1996, Pharmaceutical Powder Compaction Technology, Marcel Dekker, Inc., New York, vii-viii.

Bolhuis, G.K. and Chowhan, Z.T., 1996, Material for Direct Compaction in Alderborn, G. and Nystrom, C. (Ed.), Pharmaceutical Powder Compaction Technology, Marcel Dekker, Inc., New York, 419-447.

Rudnic, E.M. and Kottke, M.K., 1996, Tablet Dosage Forms in Banker, G.S. and Rhodes, C.T. (Ed.), Modern Pharmaceutics, 3rd Ed., Marcel Dekker, Inc., New York-Basel-Hongkong, 333-390.

DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp166-171