Synthesis,  analgesic  and  anti-inflammatory  activities  of  substituted benzoylthioureas

Tutuk Budiati; Suzana .; Siti Surdijati

doi:10.14499/indonesianjpharm0iss0pp68-76

Synthesis, analgesic and anti-inflammatory activities of substituted benzoylthioureas

Tutuk Budiati, Suzana ., Siti Surdijati

Abstract

Three compounds (i.e. benzoylthiourea, 4-nitrobenzoylthiourea, and 4-chlorobenzoylthiourea) have been synthesized from ammonium thiocyanate, substituted benzoyl chlorides, and ammonia as starting materials. The structures of sythesized compounds were confirmed by means of ultra-violet, infrared, magnetic resonance, and mass spectroscopy. All compounds were evaluated for their analgesic and anti-inflamatory activities by tail-flick technique and carragenan-induced paw oedema test respectively. Substitution of p-NO2 and p-Cl group to benzoylthiourea increased the analgesic and anti-inflamatory activities. The two compounds, 4-nitrobenzoylthiourea and 4-chlorobenzoylthiourea, were significantly more potent as analgesic but their antiinflamatory actvity was weaker than Na-diclofenac.

Keywords: benzoylthioureas, p-Cl dan p-NO2substituents, analgesic and anti-inflamator activities

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DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp68-76