Freeze drying and calcining hydrotalcite for improving acid neutralizing capacity

Deny Puriyani Azhary, Sundani Nurono Soewandhi, Saleh Wikarsa


Acid  neutralizing  capacity  (ANC)  is  one  of  the  important  factor  on effectivity  determination  of  antacid  dosage  forms.  Antacid dosage forms have different values depend on their ANC.  The objective of this research was to modified physical and chemical properties of hydrotalcite which can increase its acid neutralization capacity.  Hydrotalcite was treated by freeze drying and calcination at different temperature 100, 200, 300, and 500°C. This hydrotalcite was characterized by X-Ray Diffractometer  (XRD)  and  Scanning  Electron Microscope (SEM); and was determined acid neutralization capacity. The results showed  that  acid  neutralization  capacity  of  hydrotalcite  increased  after  it  was freeze  dried and  calcined  at  200,  300  and  500  °C.  The  result  of  XRD  for  the hydrotalcite  calcined  at  200  °C  have  showed  the  lower  intensity  of  peaks, whereas the calcination at 300 and 500 °C were disappeared and appeared new peaks at different 2θ.

Key words: Acid neutralization capacity, hydrotalcite, calcination, XRD, SEM

Full Text:

PDF 54-58


Aulton, 2002, Pharmaceutics The Science of Dosage Form Design, second edition, Churchill Livingstone,London, 390 – 393.

Bejoy, N., 2001, Hydrotalcite, The Clay That Cures, Resonance, General Article, 57 – 61.

Bera, P., 1999, Thermal behaviour of hydroxides, hydroxysalts and hydrotalcites, Bull Mater Sci,Vol. 23, No. 2, April 2000, Indian Academy of Sciences, 141–145.

Department of Health, 2008, The British Pharmacopeia, The Stationary Office under license from the Controller of Her Majesty’s Stationary Office for the Department of Health on Behalf of the Health Medicines, London, Volume I 1093 - 1094, 2226.

Erickson, K., 2004, A study of Structural Memory Effects In Synthetic Hydrotalcites Using Environmental SEM, Materials Letters, 59(2-3):p.226 – 229.

Gadad, A. P., Dandagi, P. M., Mastiholimath, V. S., Patil, M. B., Rasal, V. P., Dasankoppa, F. S., 2006, Non-chewable Antacid Formulations: Effect of Different Disintegrating Agents on Their Acid Neutralization Properties, Indian Journal of Pharmaceutical Sciences, 68, 269 – 273.

Gainotti, A., Losi, E., Colombo, P., Santi, P., Sonvico, F., Baroni, D., Massimo, G., Colombo, G., and Gaudio, P. D., 2006, The Effect of Residual water on Antacid Properties of Sucralfate gel Dried by Microwave, AAPS PharmSciTech,7,1, Article 9.

Gunawan, F., 2008, Upaya Perbaikan Daya Penetralan Asam Dari Hidrotalsit, Skripsi, ITB, Bandung.

Occelli, M. L., Olivier J. P., Auroux, A., Kalwei, M., and Eckert, H., 2003, Basicity and Porosity of a Calcined Hydrotalcite-Type Material From Nitrogen Porosimetry and Adsorption Microcalorimetry Methods, Chem. Mater, 15, 4231 – 4238.

Ramli, A., Farinaa, Md. J., and brahim, S., 2007, The Effect of Support On The Activity and Selectivity of MoVNbTe Catalyst For Propane Ammoxidation Reaction, The Malaysian Journal of Analytical Sciences, 11,.1, 124 – 132.

Soewandhi, S. N., 2005, Kristalografi Farmasi I, Penerbit ITB, Bandung, 10, 12-13

Troy, D., Williams, L., and Baltimore, Md. W., 2005, Remington’s The Science and Practice of Pharmacy, 21st ed., Lippincott Williams dan Wilkins, Baltimore Maryland, 1295



  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:

analytics View My Stats