Effect of ethanol extract of Erythrina fusca Lour (cangkring) leaves on suppression of cyclooxygenase-2 expression in raji cell line

Zullies Ikawati, Agung Endro Nugroho, Winda Werdhinindah


COX-2. COX-2 is expressed highly in inflammation and cancer cells. The effect of ethanol extract of Erythrina fusca Lour (cangkring) toward suppression of COX-2 expression in Raji cells was studied using immunocytochemistry method. This research showed that ethanol extract of E. fusca Lour leaves on concentration of 250,0; 125,0; dan 62,50 μg/mL was able to suppress the COX-2 expression significantly in comparison to control, with the inhibition of 70,19 ± 2,14 %; 44,69 ± 1,62 %; and 23,25 ± 2,21 %.

Key words: COX-2 expression, anti-inflammation, anti cancer, Raji cells, ethanol extract of E. fusca leaves, immunocytochemistry

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DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp85-90


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