Influence of PEG 4000 concentration dissolution rate of ketoprofen in solid dispersion system of ketoprofen-PEG 4000

Fikri Alatas; Sundani Nurono S.; Sukmadjaja Asyarie

doi:10.14499/indonesianjpharm0iss0pp57-62

Influence of PEG 4000 concentration dissolution rate of ketoprofen in solid dispersion system of ketoprofen-PEG 4000

Fikri Alatas, Sundani Nurono S., Sukmadjaja Asyarie

Abstract

Influence of PEG 4000 concentration dissolution rate of ketoprofen was studied in solid dispersion system of ketoprofen-PEG 4000. Solid dispersion system was prepared by melting method with various weight ratio of ketoprofen-PEG 4000, i.e. 2:1, 1:1, 1:3, and 1:4. The dissolution test was carried out using the paddle method at temperature of 37±0,5°C and 50 rotations per minute (rpm) in 900 mL of hydrochloric acid buffer solution at pH 1.2. The dissolution rate of ketoprofen improved by increasing PEG 4000 concentration. Incorporation of sodium lauryl sulfate into solid dispersion system of ketoprofen-PEG 4000 enhanced the dissolution rate of ketoprofen.

Key words : solid dispersion, ketoprofen, PEG 4000, sodium lauryl sulfate

Full Text:

Untitled

References

Abdou, H.M., 1989, Dissolution, Bioavailability and Bioequivalence, Mack Publishing Company, Pennsylvania, 53-72.

Craig, D.Q.M., 1990, Polyethylene Glycols and Drug Release, Drug Dev. Ind. Pharm. 16, 2501-2526.

Craig, D.Q.M., 2002, The Mechanisms of Drug Release From Solid Dispersion in Water-Soluble Polymers, Int. J. Pharm., 231, 131-144.

Leuner, C. and Dressman, J., 2000, Improving drug solubility for oral delivery using solid dispersion, Eur. J. Pharm. Biopharm., 50, 47-60.

Parfitt, K., 1999, Martindale, The Complete Drug Reference, Vol.1, Pharmaceutical Press, London, 48-49.

Serajuddin, A.T.M., 1999, Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs, J. Pharm. Sci. 88, 1058-1066.

Weller, P.J., 2003, Handbook of Pharmaceutical Excipient, 4th ed., The American Pharmaceutical Ass., Washington DC, 568-570.

Wulff, M., M. Alden and Craig, D.Q.M., 1996, An investigations into the critical surfactant concentration for solid solubility of hydrophobic drug in different polyethylene glycols, Int. J. Pharm. 142, 189-198.

DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp57-62