The formation of inclusion complex of phenobarbital with hydroxypropyl-β-cyclodextrine
Abstract
In the solid, inclusion complex was prepared by freezed drying method. The inclusion complex formed was characterized, compared with phenobarbital, hydroxypropyl-β-cyclodextrine, and the physical mixture of phenobarbital and hydroxypropyl-β-cyclodextrine.
Analyses using DSC and X-ray diffractometry showed that phenobarbital formed inclusion complex with hydroxypropyl-β-cyclodextrine.
Key words : phenobarbital, hydroxypropyl-β-cyclodextrine, inclusion complex
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Loftsson, T., and Brewster, M.E., 1996, Pharmaceutical Aplication of Cyclodextrin.1. Drug Solubilization and Stabilization, J. Pharm. Sci., 85 (10), 1017-1025.
Bekers, O., Uijtendaal, E.V., Beijnen, J.H., Bult, A., and Undenberg, W.J.M., 1991, Cyclodextrin in Pharmaceutical Field, Drug Dev. Ind. Pharm., 17 (11), 1503 –1549.
Isadiartuti, D., and Suwaldi, 2000, Pengaruh Senyawa Hidroksipropil-β-siklodekstrin Terhadap Kelarutan Fenobarbital, Majalah Farmasi Indonesia, 11(4), 205-208.
Kurozumi, M., Nambu, N., and Nagai, T., 1975, Inclusion Compounds of non-steroidal antiinflammatory and other slightly water soluble drugs with α and β-cyclodextrin in powdered forms, Chem. Pharm Bull, 23 (12), 3063.
Marcus K.C., 1974, Analitical profiles of Drug Substances (Florey K. Ed),7, 362-399, Academic Press, New York.
Ventura, C.A., Puglisi, G., Giammona, G., and Bottino, F.A., 1994, Comparative Study on Inclusion compounds of 4-Biphenylacetic acid with β-cyclodextrin, hidroxypropyl-β- cyclodextrin and methylated-β-cyclodextrin, Drug Dev. Ind. Pharm., 20(14), 2245-2265.
DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp28-37
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