The formation of inclusion complex of phenobarbital with hydroxypropyl-β-cyclodextrine

Dewi Isadiartuti, Suwaldi .


Phenobarbital, a hypnotic and sedative agent, was found to form inclusion complex with hydroxypropyl-β-cyclodextrine at 1:1 molar ratio. The formation of inclusion complex in the solution was detected due to the increased solubility of phenobarbital and in the solid was confirmed by differential scanning calorimetry, X-Ray diffractometry, and infrared spectroscopy.
In the solid, inclusion complex was prepared by freezed drying method. The inclusion complex formed was characterized, compared with phenobarbital, hydroxypropyl-β-cyclodextrine, and the physical mixture of phenobarbital and hydroxypropyl-β-cyclodextrine.
Analyses using DSC and X-ray diffractometry showed that phenobarbital formed inclusion complex with hydroxypropyl-β-cyclodextrine.
Key words : phenobarbital, hydroxypropyl-β-cyclodextrine, inclusion complex

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