Jaspamide: Structure identification of cytotoxic and fungicide compound isolated from Stylissa flabelliformis sponges

Erna Prawita Setyowati; Sudarsono .; Subagus Wahyuono

doi:10.14499/indonesianjpharm0iss0pp12-19

Jaspamide: Structure identification of cytotoxic and fungicide compound isolated from Stylissa flabelliformis sponges

Erna Prawita Setyowati, Sudarsono ., Subagus Wahyuono

Abstract

A research on the structure identification of cytotoxic and fungicide compound of Stylissa flabelliformis sponge has been conducted. The structure identification was analysed with spectroscopy ultraviolet, MS, 1HNMR and 13C-NMR methods.
Based on the spectroscopic data and comparison with literatures, the compound was identified as jaspamide.
Key words: sponge, Stylissa flabelliformis , jaspamide, structure elucidation

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References

Crews, P., Manes., l.V and Bohler, M., 1986, Jasplakinolide, a Cyclodepsipeptide from The Marine Sponges Jaspis sp, Tetrahedron Lett. 27(25) : 2797-2800

Hooper, J.N.A., 1997, Sponge Guide: Guide to Sponge Collection and Identification, pp : 33-38, version March, Quensland Museum, Brisbane.

Hooper, J.N.A and van Soest, R.W.M., 2002, Systema Porifera : A Guide to Classification of Sponges, pp : 783-784, volume 1, Kluwer Academic, Plenum Publisher, New York.

Setyowati, E.P., Sudarsono and Wahyuono, S., 2003, Penentuan Fraksi Aktif Spons Stylissa flabelliformis yang toksik terhadap Artemia salina Leach, J.Teknosains, Seri A, IPA Jilid 16, nomor 3, hal 499-513 , Pascasarjana UGM, Yogyakarta

Setyowati, E.P., Sudarsono and Wahyuono, S., 2004, Uji Sitotoksik dan Uji Antimikroba Senyawa Bioaktif Spons Stylissa flabelliformis , MFI, Vol. 15 No. 2, Fak. Farmasi UGM, Yogyakarta

Silverstein, R.M., Basler, G.C., and Morril, T.C., 1991, 5rd, John Wiley & Sons, Inc., New York.

Zabrieskie, T.M., Klocke, J.A., Ireland, C.M., Marcus, A.H., Molinski, T.F., Faulkner, J.D., Xu, C., and Clardy, J.C., 1986, Jaspamide a modified peptide from Jaspis sp sponge with insectisidal and antifungal activity, J.Am. Chem. Soc. 108: 3123-3124

Zampella, A., Glannini, C., Debitus, C., Rousakis, C., and Auria, M.V.D., 1999, New Jasplakinolide Derivatives from the Marine Sponges Jaspis splendans Collected in Vanuatu, J. Nat. Prod. 62: 332-334

DOI: http://dx.doi.org/10.14499/indonesianjpharm0iss0pp12-19