Phosphorylation of pregelatinized maranta starch (Maranta arundinaceae L.) as theophyllin tablet matrix controlled release
The present study was carried out to investigate the effect concentration level of pregelatinized and pregelatinized marantha starch phosphate as matrix polymer on the drug release profile. Pregelatinization starch was made by heating suspension of marantha starch with drum dryer. Phosphorylation of pregelatinized maranta starch was prepared by reacting pregelatinized marantha starch with Na2HPO4 and NaHPO4 (2:3). The modified starch product was used as matrices for tablet controlled release separately by direction compression process. Theophyllin was used as a model drug hydrophobic. The dissolution test was carried out separately in 0,1 N HCl (pH 1,8) and in phosphate buffer (pH 7,2), both for 8 hours by using paddle method.The result showed that there was no significant difference (P< 0,05) among the drug release profile from different level concentration of polymeric matrices. The drug release rate was found to be governed by the type and concentration level of polymer in matrix system, polymeric concentration (25%) in matrix, the slower release rate of the drug. Release profile showed a tendency to follow zero-order kinetics from all matrix tablets, and the drug release may be controlled by combination of diffusion and erosion delivery system.
Key words: pregelatinized maranta starch phosphate, controlled release, polymeric matrices.
Alderman, D.A., 1984, A review of cellulose ether in hydrophlic matrices for oral controlled release dosage form. Int. Pharm. Technol. Prod. 5,1-9.
Anonim. 1995. Farmakope Indonesia. Edisi IV. Depkes RI, Jakarta. 107-108.
Association of Official Analytical Chemists, 1984, Official Methods of Analysis of the Assotiation of Official Analytical Chemists, 14th ed. AOAC, Inc . Arlington, Virginia
Banakar, U.V., 1992, Pharmaceutical Dissolution Testing, Marcel Dekker, New York, 319-322.
Bravo, S.A., Larmas, M.C., and Salomόn,C.J., 2002, In-vitro studies of diclofenac sodium controlled-release from biopolymeric hydrophilic matrices. J.Pharm Pharm Sci, 5(3), 213-219.
Cunningham, C.R., 1999, Maize starch and superdisintegrants in direct compression formulation. Pharm Manufac Rev., 12, 22-24.
Effionora,A., Arry, Y., and Helen, C., 2004, Kemampuan pregelatinasi pati singkong mensubstitusi mikrokristal selulosa sebagai eksipien tablet yang dibuat dengan cara cetak langsung. Sains Indonesia, 9(1), 8-11.
Hennink, W.E.,. De Jong, S.J, Bos, G.W., and Veldhuis, T.F.J., 2004, Van Nostrum, C.F.Biodegradable dextran hydrogels crosslinked by sterecomplex formation for the controlled release of pharmaceutical protein, Int. J. Pharm., 277, 99-104,.
Herman, J. Remon, J.P., 1989, Modified starches as hydrophilic matrix for controlled oral delivery.II. In vitro drug release evaluation of thermally modified starches.Int J. Pharm. 56, 65-70.
Juliano, B.O., 1964, Studies on the physicochemical properties of rice. J. Agric. Food. Chem.,12, 131- 137.
Lachman L., Herbert A.L., and Joseph L.K. 1986. The Theory and Practice of Industrial Pharmacy, Lea & Febiger, Philadelphia, 197-223.
Lenaerts V., Moussa I., Dumoulin Y., Mebsout F., Chouinard F., Szabo P., Mateescu, MA, Cartilier L., and Marchessault R., 1998,Cross-linked high amylase starch for controlled Release of drug. J. Contr. Rel., 53, 225-234.
Lieberman, H. A., L. Lachman, and J. B. Schwartz. 1989. Pharmaceutical Dosage Forms: Tablets. Vol.1. 2nd ed. Marcel Dekker, Inc, New York, 93-113.
Lipidus, H. and Lordi, N.G., 1968, Drug release from compressed hydrophilic matrix.J. Pharm. Sci. 57(8),1292-1301.
Michailova, V., Titeva, S., and Minkov E.,1998, Influence of pH on molsidomine release from unlimited swelling hydrogel matrix. Proc. 2nd Word Meeting APGI/APV, 321-322.
Mulhbacher, J., Ispas-Szabo, P., Lenaerts V., and Mateescu, M.A.,2001, Cross-linked high amylose starch derivatives as matrix for release control from high drug loading. J. Contr.Rel., 76, 51-58.
Rak, J. Chalabala,M., Mandak,M, 1983, Modified starch-New auxiliary substances in the production of tablets. Acta Fac Pharm, 37, 5-27.
Richana, N. P., Lestari, N. C., and Widowati, S., 2000, Karakterisasi bahan berpati (tapioca, garut, dan sagu) dan pemanfaatannya menjadi glukosa cair. Pros. Sem.Nas Ind. Pangan, Surabaya, 10-11 Oktober, 396-406.
Risbud, M.V., Hardikar, A.A, Bath, S.V., Bhonde, R.R., 2000, pH-sensitive freeze-dried chitosanpolyvinyl pyrolidone hydrogels as controlled release system for antibiotic delivery. J. Con. Rel., 68, 23-30.
Solarek D.B, 1986, Phosphorylated Starches and Micellaneous Inorganic Ester, in Wurzburg O.B. (ed.), Modified Starches: Properties and Uses, CRC Press, Bocaraton,Florida, 100- 102.
Swinkels, J.J.M., 1985, Sources of Starch, its Chemistry and Physics, in Starch Conversion Technology ( G.M.A. Van Beynum and J.A. Roels, Eds), Marcel Dekker, Inc, New York, 18-27.
Tadukdar, M.M.,Vincki, I., Moldenaers, and Kinget,R., 1996, Rheological characterization of xanthan and hydroxypropylmethyl cellulose with respect to controlled release drug delivery. J. Pharm. Sci., 85(5), 537-540.
The United States Pharmacopoea XXIII, 1995, The United States Pharmacopoea, Rockville, 1685.
Van Aerde, P. and Remon, J.P., 1988, In vitro evaluation of modified starches as matrix for sustained release dosage.forms. Int. J. Pharm., 45,145-152.
Wade, A. and Weller, P.J. (ed.), 2000, Hand Book of Pharmaceutrical Excipients, 2nd ed., The pharmaceutical press, London, 522-530.
- There are currently no refbacks.
Copyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Indonesian J Pharm indexed by:View My Stats