Effect of dried extract Curcuma zedoria. Rosc. orally on the some parameters of kidney function of male rat
Curcuma zedoria Rosc. has been used empirically for cancer medicine and usually used for long periods. The aim of this study is to assess the effects of dried extract Curcuma zedoria. Rosc. orally on kidney function of male rat for 12 weeks exposure. Eighty male rat (180-200g) were divided into four group, group 1 as a control group, group 2, 3 and 4 were given 9mg/200g body weight, 18 mg/200g bw and 27mg/200g bw respectively. Dried extract of Curcuma zedoria Rosc. was given daily for 12 weeks periods, serum, urine, and kidney samples were collected by killing of 5 rats in each group on week 4, 8, 12 and 16 respectively. Serum, and urine samples were analyze for creatinine,pH, specific gravity and morphological and histological of the kidney were also observed respectively
The results indicated that serum, and creatinine content, pH and specific gravity of urine were not significantly different between control and treatment group of dosage and time of exposure (P>0.05). From the results can be concluded that dried Curcuma zedoria Rosc. given orally at the dosage up to 27mg/200g bw for long periods was safe for male rats and safely to use as a traditional medicine given at the long periods of time.
Key words: Curcuma zedoria. Rosc, urine chemical, kidney.
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Bellomo, R., Kellum, JA. and Ronco, C., 2004, Defining acute renal failure, Intesive Care Med., 30(1):33-37.
Cockroft, D.W., and Gault, MH., 1976, Prediction of creatinine clearance from serum creatinine, Nephron, 16:31-34.
Dudley, RE., Svoboda, DJ., and Klassen, CD. 1982, Acute exposure to cadmium causes severe liver injury in rats. Toxicol App. Pharmacol. 65:302-312.
Gossel, TA., and Bricker JD., 1982, Principle of Clinical Toxicology. New York: Raven Press.
Levey, AS., 1990, Measurment of renal function in chronic renal disease, Kidney Int., 38(1):167-184.
Levey, AS., Bosch, JP., Lewis, JB., Greene, T., Rogers, N., and Roth, D., 1999, A more accurate method to estimate glomerular filtration rate from serum creatinine: Anew prediction equation modification of diet in renal diseases study group. Ann Intern Med., 130(6):461-470.
Manjunath, G., Sarnak,MJ., and Levey, AS., 2001, Estimating the glomeral filtration rate. Dos and don’ts for assessing kidney function, Postgrad Med., 110(6):55-62
Murwanti, R., Meiyanto, E., Nurrochmad, A. and Kristina, SA., 2004, Efek ekstrak etanol rimpang temu putih (Curcuma zedoria Rosc.) terhadap pertumbuhan tumor paru fase post inisiasi pada mencit betina diinduksi Benzo(a)piren. Majalah Farmasi Indonesia, 15(1):7-12
Nissl, J.R.N., Van houten, S., Landaner, T., Burgess, P., and Mendelssohn, D.J, 2004, Creatinine and clearance. Nephrology 20(2004)
Surh, Y., 1999, Molekuler mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substance, British J. Cancer, 80(1-2):1-10.
Soewarni M, 1997, Efek antiradang minyak atsiri temu putih (Curcuma zedoria Rosc ) terhadap udem buatan pada tikus putih buatan galur Wistar, Majalah Farmasi Indonesia, 8(1):34-41.
Windono, M.S. and Parfiani, N. 2002, Curcuma zedoria Rosc., Kajian pustaka kandungan kimia dan aktivitas farmakologik, Artocarpus, 2(1):1-10.
Syu, WJ., Shen, CC., Don, MJ., Ou, JC., Lee, GH., and Sun, CM., 1988, Cytotoxicity of curcuminoids and some novel compounds from Curcuma zedoria, Journal of Natural Product, 61(12): 1532-1534.
Yoshioka, T., Fujii, E., Endo, M., Hosho, H., Shibuya, H., and Uraki, T., 1998, Antiinflamatory Potency of Dehydrocurdione, A Zedoary-derived Sesquiterpen (Abstr), Inflamm Res, 47(12):476-481.
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