Liver and kidney histopathological test of mice received Pauh Kijang (Irvingia malayana Oliv ex A. Benn) extract

Praptiwi ., Dewi Ratih Agungpriyono, Esti Rahayu


The background of this study was to determine the safety of pauh kijang extract which is orally given to mice while the aim of the study was to evaluate the liver and kidney histopathological changes after receiving various dose of the extract mango (Irvingia malayana Oliv. Exe Benth.) ethanol extract. There were five group of treatments in this study : mice received extract with the concentration of (I) 1000mg /kg BW, (II)100 mg/kg BW, (III) 10 mg/kg BW, (IV) 1 mg/kg BW, and (V) received carboxy methyl cellulose-sodium (CMC-Na) as negative control. Each treatment consisted of five mice. After seven days of treatment, mice were sacrified. The liver and kidney were sampled and processed to prepare histopathology slides. The histopathology parameters were examined by counting the degeneration and necrotic cells of hepatocytes and renal epithelial tubule. The lesion of glomerulus such as atrophy and protein sedimentation were also observed. The result also showed that extract concentration of > 10 mg/kg BW result in damaging liver cells significantly, while kidney cell damage occurred significantly in the exposure of extract > 1 mg/kg BW.

Key words : Irvingia malayana, liver, kidney

Full Text:

pdf 172-177


Carlton W. W and McGavin M. D. 1995. Thomson’s Special Veterinary Pathology. Mosby-Year Book,

Inc. St. Louis.

Cheville, N. F. 2006. Cell Death and Cell Recovery. In : Introduction of Veterinary Pathology. 3rd Ed. Blackwell Publishing. USA.

Cotran RS, Kumar V and Robbins S. 1989. Pathologi Basics of Disease 4th Ed. WB Saunders Company.


Heyne K. 1987. Tumbuhan Berguna Indonesia Jilid 2. Badan Penelitian dan Pengembangan Kehutanan.

Yayasan Wana Jaya. Jakarta.

Hock B and Elsner E. F. 2005. Plant Toxicology 4ed. Marce Dekker. New York.

Lu FC. 1995. Toksikologi Dasar. Edisi 2. Univ. Indonesia Press. Jakarta.



  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:

analytics View My Stats