Formulation, Characterization and Stability of Ibuprofen-Loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS)

Yandi Syukri; Hannie Fitriani; Herianto Pandapotan; Bambang Hernawan Nugroho

doi:10.14499/indonesianjpharm30iss2pp105-113

Formulation, Characterization and Stability of Ibuprofen-Loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS)

Yandi Syukri, Hannie Fitriani, Herianto Pandapotan, Bambang Hernawan Nugroho

Abstract

Ibuprofen is a poorly water-soluble drug with analgesic, antipyretic and anti-inflammatory effects. Self-Nano Emulsifying Drug Delivery System (SNEDDS) formulation is a solution to improve the solubility and bioavailability of ibuprofen. This research purposed to perform a formulation, characterization, and stability studies of ibuprofen-loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS). Screening of ibuprofen SNEDDS was prepared by ternary diagrams for the chosen co-surfactants, surfactants, and oil. The following was characterizations of droplet size, zeta potential, and clarity. The solubility test for the determination of co-surfactant, surfactant, and oil obtained Propylene glycol monocaprylate (Capryol-90), Polysorbate 20 (Tween 20) and PEG 400. The screening of SNEDDS showed nine formulas (compositions) in the range concentration of Propylene glycol monocaprylate (1-3 mL), Polysorbate 20 (4-8 mL), and PEG 400 (1-3 mL). The composition of Propylene glycol monocaprylate (1-2 mL), Polysorbate 20 (5-8 mL) and PEG 400 (1-3 mL) passed the thermodynamic stability test. The test of robustness to dilution and stability study indicated that the formula with Propylene glycol monocaprylate, Polysorbate 20 and PEG 400 with the ratio of 1: 8: 1 and 1: 7: 2 was more stable. In conclusion, the stable ibuprofen SNEDDS could be prepared with Propylene glycol monocaprylate, Polysorbate 20, and PEG 400.

Keywords

Ibuprofen, SNEDDS, characterization, stability

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References

Agrawal, A. G., Kumar, A., & Gide, P. S. (2015). Self-emulsifying drug delivery system for enhanced solubility and dissolution of glipizide. Colloids and Surfaces B: Biointerfaces, 126, 553–560. https://doi.org/10.1016/j.colsurfb.2014.11.022

Álvarez, C., Núñez, I., Torrado, J. J., Gordon, J., Potthast, H., & García-Arieta, A. (2011). Investigation on the Possibility of Biowaivers for Ibuprofen. Journal of Pharmaceutical Sciences, 100(6), 2343–2349. https://doi.org/10.1002/jps.22472

Balakumar, K., Raghavan, C. V., selvan, N. T., prasad, R. H., & Abdu, S. (2013). Self-nanoemulsifying drug delivery system (SNEDDS) of Rosuvastatin calcium: Design, formulation, bioavailability and pharmacokinetic evaluation. Colloids and Surfaces B: Biointerfaces, 112, 337–343. https://doi.org/10.1016/j.colsurfb.2013.08.025

Balakumar, K., Vijaya Raghavan, C., Tamil Selvan, N., & Habibur Rahman, S. M. (2013). Self-emulsifying drug delivery system: Optimization and its prototype for various compositions of oils, surfactants and co-surfactants. Journal of Pharmacy Research, 6(5), 510–514. https://doi.org/10.1016/j.jopr.2013.04.031

Dash, R. N., Mohammed, H., Humaira, T., & Ramesh, D. (2015a). Design, optimization and evaluation of glipizide solid self-nanoemulsifying drug delivery for enhanced solubility and dissolution. Saudi Pharmaceutical Journal, 23(5), 528–540. https://doi.org/10.1016/j.jsps.2015.01.024

Dash, R. N., Mohammed, H., Humaira, T., & Ramesh, D. (2015b). Design, optimization and evaluation of glipizide solid self-nanoemulsifying drug delivery for enhanced solubility and dissolution. Saudi Pharmaceutical Journal, 23(5), 528–540. https://doi.org/10.1016/j.jsps.2015.01.024

Deng, Y., Yang, F., Zhao, X., Wang, L., Wu, W., Zu, C., & Wu, M. (2018). Improving the skin penetration and antifebrile activity of ibuprofen by preparing nanoparticles using emulsion solvent evaporation method. European Journal of Pharmaceutical Sciences, 114, 293–302. https://doi.org/10.1016/j.ejps.2017.12.024

Elnaggar, Y. S. R., El-Massik, M. A., & Abdallah, O. Y. (2009). Self-nanoemulsifying drug delivery systems of tamoxifen citrate: Design and optimization. International Journal of Pharmaceutics, 380(1–2), 133–141. https://doi.org/10.1016/j.ijpharm.2009.07.015

Heshmati, N., Cheng, X., Eisenbrand, G., & Fricker, G. (2013). Enhancement of Oral Bioavailability of E804 by Self-Nanoemulsifying Drug Delivery System (SNEDDS) in Rats. Journal of Pharmaceutical Sciences, 102(10), 3792–3799. https://doi.org/10.1002/jps.23696

Kassem, A. A., Mohsen, A. M., Ahmed, R. S., & Essam, T. M. (2016). Self-nanoemulsifying drug delivery system (SNEDDS) with enhanced solubilization of nystatin for treatment of oral candidiasis: Design, optimization, in vitro and in vivo evaluation. Journal of Molecular Liquids, 218, 219–232. https://doi.org/10.1016/j.molliq.2016.02.081

Kuentz, M. (2012). Lipid-based formulations for oral delivery of lipophilic drugs. Drug Discovery Today: Technologies, 9(2), e97–e104. https://doi.org/10.1016/j.ddtec.2012.03.002

Nagi, A., Iqbal, B., Kumar, S., Sharma, S., Ali, J., & Baboota, S. (2017). Quality by design based silymarin nanoemulsion for enhancement of oral bioavailability. Journal of Drug Delivery Science and Technology, 40, 35–44. https://doi.org/10.1016/j.jddst.2017.05.019

Nekkanti, V., Rueda, J., Wang, Z., & Betageri, G. V. (2016). Comparative evaluation of proliposomes and self-micro emulsifying drug delivery system for improved oral bioavailability of nisoldipine. International Journal of Pharmaceutics, 505(1–2), 79–88. https://doi.org/10.1016/j.ijpharm.2016.03.065

Parmar, N., Singla, N., Amin, S., & Kohli, K. (2011). Study of cosurfactant effect on nanoemulsifying area and development of lercanidipine loaded (SNEDDS) self-nanoemulsifying drug delivery system. Colloids and Surfaces B: Biointerfaces, 86(2), 327–338. https://doi.org/10.1016/j.colsurfb.2011.04.016

Senapati, P. C., Sahoo, S. K., & Sahu, A. N. (2016). Mixed surfactant based (SNEDDS) self-nanoemulsifying drug delivery system presenting efavirenz for enhancement of oral bioavailability. Biomedicine & Pharmacotherapy, 80, 42–51. https://doi.org/10.1016/j.biopha.2016.02.039

Shafiq-un-Nabi, S., Shakeel, F., Talegaonkar, S., Ali, J., Baboota, S., Ahuja, A., … Ali, M. (2007). Formulation development and optimization using nanoemulsion technique: A technical note. AAPS PharmSciTech, 8(2), E12–E17. https://doi.org/10.1208/pt0802028

Shahba, A. A.-W., Mohsin, K., & Alanazi, F. K. (2012). Novel Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Oral Delivery of Cinnarizine: Design, Optimization, and In-Vitro Assessment. AAPS PharmSciTech, 13(3), 967–977. https://doi.org/10.1208/s12249-012-9821-4

Shehata, E. M. M., Elnaggar, Y. S. R., Galal, S., & Abdallah, O. Y. (2016). Self-emulsifying phospholipid pre-concentrates (SEPPs) for improved oral delivery of the anti-cancer genistein: Development, appraisal and ex-vivo intestinal permeation. International Journal of Pharmaceutics, 511(2), 745–756. https://doi.org/10.1016/j.ijpharm.2016.07.078

Sriamornsak, P., Limmatvapirat, S., Piriyaprasarth, S., Mansukmanee, P., & Huang, Z. (2015). A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution. Asian Journal of Pharmaceutical Sciences, 10(2), 121–127. https://doi.org/10.1016/j.ajps.2014.10.003

DOI: http://dx.doi.org/10.14499/indonesianjpharm30iss2pp105-113