Chinmaya Keshari Sahoo, Surepalli Ram Mohan Rao, Muvvala Sudhakar


The present study was undertaken to develop controlled release osmotic pump tablets of lamivudine a nucleoside reverse transcriptase inhibitor for the treatment of acquired immune deficiency syndrome (AIDS).The tablets were prepared by wet granulation method using controlled release polymer hydroxyl propyl methyl cellulose (HPMCE5 LV), MCC as diluent, starch as binder and fructose as osmogen. The coating solution of core tablets were prepared by using cellulose acetate,poly ethylene glycol 400,600,4000,6000 and acetone to quantity sufficient with sorbitol for different batches. The prepared tablets were evaluated for pre compression parameters, post compression parameters, in vitro drug release study and scanning electron microscopy study. Among the prepared formulations LF4 batch show 97.78% drug release in 12hrs.The in vitro release kinetics were analyzed for different batches by different pharmacokinetic models such as zero order, first order,Higuchi,Korsmeyer Peppas and Hixon Crowell model. Short term stability study at 40±2ºC/75±5% RH for three months on the best formulation was performed showing no significant changes in thickness, hardness, friability, drug content and in vitro drug release.


AIDS; wet granulation; in vitro drug release; stability study

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Dasankoppa FS.,Ningangowdar M.,Sholapur H., 2013.Formulation and evaluation of controlled porosity osmotic pump for oral delivery of ketorolac. Journal of Basic and Clinical Pharmacy.4(1):2-9.

Edavalath S.,Shivanand K.,Prakasam K.,Rao BP.,Divakar G..2011.Formulation development and optimization of controlled porosity osmotic pump tablets of diclofenac sodium.Int.J.Pharm.Pharm.Sci.3(1):80-87.

Higuchi T., 1963.Mechanism of sustained action medication theoretical analysis of rate of release of solid drugs dispersed in solid matrices.J Pharm Sci 52:1145-1149

Hixson AW, Crowell JH., 1931.Dependence of reaction velocity upon surface and agitation, Ind.Eng.Chem. 23:923-931.

Kaushal AM., Garg S., 2003.An update on osmotic drug delivery patents. Pharm. Tech., 27: 38-44

Kumaravelrajan R., Narayanan N., Suba V.,2011. Development and evaluation of controlled porosity osmotic pump for Nifedipine and Metoprolol combination.Lipids in Health and Disease.10:51

Kanagale P., Lohray BB., Misra A., Davadra P.,Kini R.,2007.Formulation and Optimization of Porous Osmotic Pump based Controlled Release System of Oxybutynin.AAPS Pharm SciTech. 8(3):E1-E7

Korsmeyer RW,Gunny R,Docler E,Buri P,Peppas NA., 1983.Mechanism of solute release from porous hydrophilic polymers Int.J.Pharm.15:25-35

Maheswari U,Elango K,Chellakumari D,Saravanan K,Samy AJ.,2012.Formulation and evaluation of controlled porosity osmotic tablets of lornoxicam.Int.J. of Pharmaceutical Sciences and Research 3(6):1625-1631.

Pragathi NA,2015. Effect of different diluents on release profile of Lamivudine from sustained release matrix tablet using kollidon SR as release retardant, International Journal of Research in Pharmaceutical and Nano Sciences, 4(2): 50-59.

Presscott LF.,1989. The need for improved drug delivery in clinical practice in Novel Drug Delivery and its Therapeutic applications. West Susset ,UK: John Wiley and Sons; 1-11.

Patel H,Patel UD,Kadikar H,Bhimani B,Daslaniya D,Patel G.,2012.Formulation and evaluation of controlled porosity osmotic pump tablets of glimepiride. Inter J Drg Del 4(1):113-24.

Patel H, Patel MM.,2012.Formulation and evaluation of controlled porosity osmotic drug delivery system of carvedilol phosphate. Journal of Pharmaceutical Science and Bioscientific Research.2(2):77-82.

Rani M,Mishra B.,2004.Comparative in vitro and in vivo evaluation of matrix,osmotic matrix and osmotic pump tablets for controlled delivery of diclofenac sodium.AAPS Pharm.Sci Tech.5(4):1-7.

Rao BP,Geetha M,Purushothama N,Sanki U.,2009.Optimization and development of swellable controlled porosity osmotic pump tablet for theophylline.Trop. J. Pharm Res.8(3):247-255.

Richman DD.,2001. HIV chemotherapy. Nature 410, 995-1001,2001

Sahoo CK,Sahoo TK,Moharana AK,Panda KC.,2012.Formulation and optimization of porous osmotic pump based controlled release system of Residronate sodium for the treatment of postmenopausal osteoporosis.Int.Journal of Pharmaceutical Sciences Review and Research 12(1):118-122.

Sahoo CK,Sahoo NK,Rao SRM,Sudhakar M,Satyanarayana K.,2015.Areview on controlled porosity osmotic pump tablets and its evaluation. Bulletin of Faculty of Pharmacy,Cairo University,53(2):195-205.

Sahoo CK,Rao SRM,Sudhakar M.,2015.Evaluation of controlled porosity osmotic pump tablets a review.Research J. Pharm. And Tech. 8(12):119-125.

Sahoo CK,Rao SRM,Sudhakar M., Kokkula S.,2015.The kinetic modeling of drug dissolution for drug delivery systems: an overview.Der Pharmacia Lettre 7(9):186-194.

Sahoo CK,Rao SRM and Sudhakar M.,2015.A review on human immunity system and HIV infection. Int. J. of Current Pharmaceutical Review and research 6(6):262-268.

Sahoo CK,Rao SRM,Sudhakar M,Bhaskar J.,2016.Advances in granulation technology.Research J.Pharm. and Tech. 9(5):571-580.

Sharma F,Jain H,Kanzariya V,Upadhyay U.,2014. Formulation and evaluation of controlled release osmotic tablet of metoprolol succinate.Asian J. Pharm Clin Res 7(3):38-43.

Shah N,Patel K.,2013.Design and development of controlled porosity osmotic tablets of captopril. J. of Pharmaceutical Science and Bioscientific Research.3(4):145-150.

The USP 26-National Formulary 21 Rockville MD US Pharmacopoeial Convention 2003.

Verma RK,Garg S.,2004.Development and evaluation of osmotically controlled oral drug delivery system of glipizide.Europpean Journal of Pharmaceutics and Biopharmaceutics 57:513-525.

Zenter GM, Rork GS, Himmelstein KJ., 1985. The controlled porosity osmotic pump. J control release; 1:269-282.



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