THE DISSOLUTION AND DIFFUSION OF FUROSEMIDE ON  SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS)

iis - wahyuningsih; Sugiyanto Sugiyanto; Ag. Yuswanto; Ronny Martien

doi:10.14499/indonesianjpharm28iss2pp112

THE DISSOLUTION AND DIFFUSION OF FUROSEMIDE ON SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS)

iis - wahyuningsih, Sugiyanto Sugiyanto, Ag. Yuswanto, Ronny Martien

Abstract

Furosemide a diuretic exhibits low solubility in water and low bioavailability. The purpose of this study was to determine the effect SNEDDS formation to dissolution and diffusion of furosemide. SNEDDS was made with a mixture of 66% tween 80, 26% propylene glycol, 8% oleic acid and furosemide 40mg/mL. Test for SNEDDS dissolution of the capsules was developed using USP dissolution apparatus I and compared to market products, furosemide suspenssion and furosemide powder. The medium consists of 900mL of Artificial Gastric Fluid (AGF) , phosphate buffer pH 5.8 at 37±0.5°C and stirred with a speed of 100rpm. Diffusion test of SNEDDS furosemide was conducted by using reversed rat intestinal bowel and compared to furosemide suspension and furosemide solution. The SNEDDS formulation could enhance the dissolution and diffusion of furosemide compared to the non-SNEDDS formulation

Keywords

furosemide, SNEDDS, dissolution, diffusion

Full Text:

PDF

References

Acharya, S.P., Pundarikakshudu, K., Panchal, A., Lalwani, A., 2013. Preparation and evaluation of transnasal microemulsion of carbamazepine. Asian J. Pharm. Sci. 8, 64–70. doi:10.1016/j.ajps.2013.07.008

Al-Mohizea, A.M., 2010. Influence of intestinal efflux pumps on the absorption and transport of furosemide. Saudi Pharm. J. SPJ 18, 97–101. doi:10.1016/j.jsps.2010.02.005

Amrutkar, C., Salunkhe, K., Chaudhari, S., 2014. Study on Self Nano Emulsifying Drug Delivery System of Poorly Water Soluble Drug Rosuvastatin Calcium. World J. Pharm. Res. 3, 2137–2151.

Bali, V., Ali, M., Ali, J., 2010. Study of surfactant combinations and development of a novel nanoemulsion for minimising variations in bioavailability of ezetimibe. Colloids Surf. B Biointerfaces 76, 410–420. doi:10.1016/j.colsurfb.2009.11.021

Basalious, E.B., Shawky, N., Badr-Eldin, S.M., 2010. SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: development and optimization. Int. J. Pharm. 391, 203–211. doi:10.1016/j.ijpharm.2010.03.008

Berkó, S., Regdon Jr., G., Ducza, E., Falkay, G., Erős, I., 2002. In vitro and in vivo study in rats of rectal suppositories containing furosemide. Eur. J. Pharm. Biopharm. 53, 311–315. doi:10.1016/S0939-6411(02)00005-X

Custodio, J.M., Wu, C.Y., Benet, L.Z., 2008. Predicting drug disposition, absorption elimination btransporter interplay and the role of food on drug absorption. Adv. Drug Deliv. Rev. 60, 717–733. doi:10.1016/j.addr.2007.08.043

Doh, H.J., Jung, Y., Balakrishnan, P., Cho, H.J., Kim, D.D., 2013. A novel lipid nanoemulsion system for improved permeation of granisetron. Colloids Surf. B Biointerfaces 101, 475–480. doi:10.1016/j.colsurfb.2012.07.019

Gupta, S., Chavhan, S., Sawant, K.K., 2011. Self-nanoemulsifying drug delivery system for adefovir dipivoxil: Design, characterization, in vitro and ex vivo evaluation. Colloids Surf. Physicochem. Eng. Asp. 392, 145–155. doi:10.1016/j.colsurfa.2011.09.048

Hadgraft, J., Walters, K.A., 1993. Pharmaceutical Skin Penetration Enhancement.

Kale, A.A., Patravale, V.B., 2008. Design and evaluation of self-emulsifying drug delivery systems (SEDDS) of nimodipine. AAPS PharmSciTech 9, 191–196. doi:10.1208/s12249-008-9037-9

Lindenberg, M., Kopp, S., Dressman, J.B., 2004. Classification of orally administered drugs on the World Health Organization Model list of Essential Medicines according to the biopharmaceutics classification system. Eur. J. Pharm. Biopharm. Off. J. Arbeitsgemeinschaft Für Pharm. Verfahrenstechnik EV 58, 265–278. doi:10.1016/j.ejpb.2004.03.001

Makadia, M.H.A., Bhatt, M.A.Y., Parmar, M.R.B., Paun, M.J.S., Tank, D.H.M., 2013. Self-nano Emulsifying Drug Delivery System (SNEDDS): Future Aspects. Int. J. Technol. 3, 21-27.

Miryala, V., Kurakula, M., 2013. Self-Nano Emulsifying Drug Delivery System (SNEDDS) for Oral Delivery of Atorvastatin- Formulation and Bioavailability Studies. J. Drug Deliv. Ther. 3, 131–142.

Mohsin, K., Shahba, A.A., Alanazi, F.K., 2012. Lipid Based Self Emulsifying Formulations for Poorly Water Soluble Drugs-An Excellent Opportunity. ResearchGate 46, 88–96.

Nazzal, S., Smalyukh, I.I., Lavrentovich, O.D., Khan, M.A., 2002. Preparation and in vitro characterization of a eutectic based semisolid self-nanoemulsified drug delivery system (SNEDDS) of ubiquinone: mechanism and progress of emulsion formation. Int. J. Pharm. 235, 247–265.

O’Driscoll, C.M., 2002. Lipid-based formulations for intestinal lymphatic delivery. Eur. J. Pharm. Sci. Off. J. Eur. Fed. Pharm. Sci. 15, 405–415.

Porter, C.J.H., Pouton, C.W., Cuine, J.F., Charman, W.N., 2008. Enhancing intestinal drug solubilisation using lipid-based delivery systems. Adv. Drug Deliv. Rev. 60, 673–691. doi:10.1016/j.addr.2007.10.014

Prabhakar, K., Afzal, S.M., Surender, G., Kishan, V., 2013. Tween 80 containing lipid nanoemulsions for delivery of indinavir to brain. Acta Pharm. Sin. B 3, 345–353. doi:10.1016/j.apsb.2013.08.001

Rajesh, B.., Reddy, T.., Srikanth, G., Mallikarjun, V., Nivethithai, P., 2010. Lipid Based Self-emulsifying Drug Delivery System (SEDDS) for Poorly water-soluble Drugs: A Review. JGlob Pharma Technol 2, 47–55.

Shaji, J., Jadhav, D., 2010. Newer Approches to Self Emulsifying Drug Delivery System. Int. J. Pharm. Pharm. Sci. 2, 37–42.

Swaroopa, A., Aparna, C., Srinivas, P., 2014. Formulation, Evaluation and Characterization of Periodontal Microemulsion Gel. Int. J. Pharm. Sci. Drug Res. 6, 20–25.

Trommer, H., Neubert, R.H.H., 2006. Overcoming the stratum corneum: the modulation of skin penetration. A review. Skin Pharmacol. Physiol. 19, 106–121. doi:10.1159/000091978

Wahyuningsih, I., Sugiyanto, Yuswanto, A., Martien, R., 2016, Optimasi dan Karakterisasi Formula SNEDDS Furosemid, Laporan Penelitian.

Wang, L., Dong, J., Chen, J., Eastoe, J., Li, X., 2009. Design and optimization of a new self-nanoemulsifying drug delivery system. J. Colloid Interface Sci. 330, 443–448. doi:10.1016/j.jcis.2008.10.077

Williams, A.C., Barry, B.W., 2004. Penetration enhancers. Adv. Drug Deliv. Rev. 56, 603–618. doi:10.1016/j.addr.2003.10.025

Xia, D., Quan, P., Piao, H., Piao, H., Sun, S., Yin, Y., Cui, F., 2010. Preparation of stable nitrendipine nanosuspensions using the precipitation-ultrasonication method for enhancement of dissolution and oral bioavailability. Eur. J. Pharm. Sci. Off. J. Eur. Fed. Pharm. Sci. 40, 325–334. doi:10.1016/j.ejps.2010.04.006

Yu, B., Kim, K.H., So, P.T.C., Blankschtein, D., Langer, R., 2003. Visualization of oleic acid-induced transdermal diffusion pathways using two-photon fluorescence microscopy. J. Invest. Dermatol. 120, 448–455. doi:10.1046/j.1523-1747.2003.12061.x

Zhao, T., 2015. Self-nanoemulsifying drug delivery systems (SNEDDS) for the oral delivery of lipophilic drugs. University of Trento.

DOI: http://dx.doi.org/10.14499/indonesianjpharm28iss2pp112