Lina Winarti, Lidya Ameliana, Dwi Nurahmanto


Meloxicam is one of oxicams anti-inflamatory drugs that are effective to relieve toothaches, arthritis, dysmenorrhea, and fever. Meloxicam in this study was milled with High Energy Milling (HEM) method to obtain its nano size and then direct compression method was used to produce Orally Disintegrating Tablet (ODT). ODT is designed to be rapidly dissolved on the tongue within a minute. It can be administered without water or chewing and may improve the bioavailability and effectiveness of the drug, and increase the patient’s adherence. The present study aimed to understand the effects of Ac-Di-Sol and Kollidon CL as superdisintegrants, that were used separately or in combination, on the characteristics of nanoparticles meloxicam ODT. It was also to obtain the best proportion of combination between Ac-Di-Sol and Kollidon CL that can produce the optimum formula of meloxicam ODT. The effects of single or combined superdisintegrants were evaluated using Simplex Lattice Design (SLD). Ac-Di-Sol (X1) and Kollidon CL (X2) were the independent variables, while the dependent variables were friability (Y1), disintegrating time (Y2), wetting time (Y3), and percent meloxicam release after 60 seconds (Y4). Optimization of five nanoparticle meloxicam ODT formulas was conducted using Design Expert 7.1.5. The combination of Ac-Di-Sol 4.05mg (X1) and Kollidon CL 10.95mg (X2) in 150mg nanoparticles meloxicam ODT can produce optimal ODT characteristics. After verification there was no difference between predicted value and observed value with p value > 0.05.


orally disintegrating tablet (ODT); meloxicam; milling; nanoparticles

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Ahmed I., Aboul-Einen M., 2007. In vitro and in vivo evaluation of a fast disintegrating lyophylized drug emulsion tablet containing griseofulvin. Eur. J. Pharm. Sci. 32:58-68.

Banker GS., Anderson NR., 1986. Tablets. In Lachman L., Lieberman HA., Kanig JL., editors. The theory and practice of industrial pharmacy. 3th edition. Philadelphia. PA. Lea & Febiger. p 293-345.

Bhowmik D., Chiranjib B., Krishnakanth, Pankaj, Margret R., 2009. Fast Dissolving Tablet: An Overview. J. Chem. Pahrmaceut. Res. 1(1): 163-177.

Bustos FM., Soto ML., Martinez ESM., Morales JJZ., Velez-Medina JJ., 2007. Effects of high energy milling on some functional properties of Jicama starch (pachyrrhizus crosus L.urban) and cassava starch (Mannihot esculenta crantz), Journal of food engineering. 78:1212-1220.

Camarco WD., Ray, Drufftner A., 2006. Selecting superdisintegrants for orally disintegrating tablet formulations. Pharm. Tech. supplement. s28-s37.

Elbary AA., Ali AA., Abond HM., 2012. Enhanced dissolution of meloxicam from orodispersible tablets prepared by different methods.Bulletin of faculty of pharmacy Cairo university.50(2) pp:89-97.

Galal EL., Mahrouk, Aboul-Einen M., Adel N., 2009. Formulation and evaluation of meloxicam orally dispersible capsules. Asian J. Pharm. Sci. 4(1):8-22.

Gohel M., Patel M., Amin A., Agrawal R., Dave R., Bariya N., 2004. Formulation design and optimization of mouth dissolve tablets of nimesulide using vacuum drying technique. AAPS Pharm.Sci.Tech. 5(3):36.

Hirani JJ., Rathod DA., Vadalla KR., 2009. Orally disintegrating tablets: A review.Trop.J.Pharm.Res. 8(2):161-172

Indonesia Pharmacope.1979.3th edition.Health Department of Republic Indonesia.Jakarta

Indonesia Pharmacope.2014.5th edition.Health Department of Republic Indonesia.Jakarta

Kornblum SS., Stoppak SB., 1973. A new tablet disintegrating agent:crosslinked polyvinylpyrrolidone. J.Pharm.sci. 62, 43-49

Kosek T., Onishi H., Takahashi Y., Uchida M., Machida Y., 2008. Development of Novel Fast-Disintegrating Tablets by Direct Compression Using Sucrose Stearic Acid Esters as A Disintegration-Accelerating Agent. Chem. Pharm. Bull. 56(10): 1384-1388.

Kulkarni SV, Kumar R, Nikunj P., Rao S., Ramesh B, Kumar A., 2011. Formulation and evaluation of fast disintegrating meloxicam tablets and its comparison with marketed produck. Int.J.Pharm.Pharm.Sci. 3(1) pp 91-93.

Lachman L., Liebermann HA., Kanig JI., 1994. The theory and practice of industrial pharmacy. 3th edition.UI Press, Jakarta.645

Mohamed MB., Talari MK., Tripathy M., Majeed ABA., 2012. Pharmaceutical application of crospovidone:A review. IJDFR. 3(1), 3-28.

Möschwitzher J., Müller RH., 2007. Drug Nanocrystals-The Universal Formulation Approach for Poorly Soluble Drugs. In: D. Thassu, M. Deleers dan Y. Pathak (eds). Nanoparticulate Drug Delivery Systems. New York: Informa Healthcare USA, Inc. Pages 72-73, 77-78.

Panigrahi R., Behera SA., 2010. A review on fast dissolving tablets.(ONLINE) available at: (accessed 15 February 2015).

Quadir A., Kolter K., 2006. A comparative study of current superdisintegrants. Pharm.Technol. 38-42.

Rahman Z., Zidan AS., Khan MA., 2010. Resperidone solid dispersion for orally disintegrating tablet:its formulation design and non-destructive methods of evaluation. Int.Journal of pharmaceutics. 400(1):pp49-58.

Saleem MA., Bala S., 2010. Formulation and Evaluation of Meloksikam Solid Dispersion Incorporated Topical Gels. IJPBS, Vol 1(3): 1-9.

Samprasit W., Akkaramongkolporn P., Ngawhiruhpat T., Rojanavata T., Opanasopit P., 2013. Meloxicam taste-masked oral disintegrating tablet with dissolution enhanced by ion exchange resins and cyclodextrin. AAPS.PharmSciTech.14(30:1118-1128.

Sharma K., Pfister WR., Gosh TK., 2005. Quick dispersing oral drug delivery systems. In:TK Gosh, Pfister WR (eds).drug Delivery to the oral cavity:Molecules to market, Bola raton:Taylor & Francis Group.pp:262-263.

Singhvi G., Gampa G., Yadav N., Kumar V., Ukawala R., 2013. Design and evaluation of rapidly disintegrating tablets of racecadotril with enhanced in vitro dissolution achieved by solid dispersion technique.

Indian.J.Pharmaceut. edu.Res. 47(3).

Tanuwijaya J., Karsono, Urip H., 2014. Characterization of piroxicam nanoparticles in orally disintegrating tablet (ODT). Int.J.ChemTech.Res. 6(2), 11955-961.

Wiradjaja FS., Saifullah TN., 2015. Optimization of Orally disintegrating tablet (ODT) by inclusions complex between meloxicam and β-cyclodextrin using Ac-Di-Sol and Kollidon CL as superdisintegrants and Avicel PH 200 as filler binder.Thesis.Faculty of Pharmacy.Gadjah Mada University.Indonesia



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