Raju Rameshrao Thenge, V B Patond, P V Ajmire, L N Barde, N M Mahajan, N P Tekade


Diacerein, anti-inflammatory drug used in the treatment of osteoarthritis. Being a BCS class II drug, it has poor solubility, dissolution rate and other physicochemical properties. Thus the aim of present study was to prepare co-crystals of diacerein to improve solubility, dissolution rate. The diacerein co-crystals were prepared using urea and tartaric acid as conformer by Solvent drop grinding method. The diacerein co-crystals were characterized by scanning electron microscopy (SEM), FT-IR spectroscopy (FT-IR), Differential scanning calorimetry (DSC) and X-ray diffractometry (XRD). The co-crystals were evaluated for solubility, dissolution rate and other physicochemical properties and compared with commercial diacern sample. The co-crystals exhibit the difference in the size and shape of crystals. The FT-IR spectra of diacerein co-crystals showed slightly different in the characteristic peaks compared to commercial diacerein sample. DSC data indicate the decrease in the melting endotherm of co-crystals compare to diacerein. The co-crystals with urea showed increase and intense peak and co-crystals with tartaric acid showed decreased number of peaks compared to commercial diacerein. The co-crystals of diacerein formulated in to the Tablet and evaluated for tablet properties. The tablet formulation showed improved tablet characteristics as well as dissolution rate compared to commercial diacerein.


Co-crystals; Diacerein; physicochemical properties; FT-IR

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Anindita S., Sohrab R., 2014,Co-crystals of Acyclovir with promising physicochemical properties, J. Pharma. Sci, Vol-104, Issue-1, pp.98-105.

Deshmukh DB. et al,. 2010, Dissolution Enhancement of Poorly Water Soluble Diacerein By Solid Dispersion Technique. J. Pharm. Sci. Res. 2:734-739.

Gagniere E., Margin D., Puel P., Rivoire A., Monnier O. 2009, Formation of co-crystal kinetic and thermodynamic aspects. J.Crystal Growth;11: 2689-2695.

Harry G., Brittain. 2006, Polymorph in Pharmaceutical solids. Mercel Dekker publication,7:1-2.

Hickey M., Peterson M., Scoppettuolo L., Morrisette S. 2007; Performance com-parison of co-crystal of Carbamazepine with marketed product, Eur. J Pharm. Biopharm., 67: 112-119.

Lachman L., Lieberman H., 1991, The theory and practice of Industrial Pharmacy. Third Editon; Varghese publishing house, 3:180.

Mahajan A., Singh K., Tandon VR., 2006, Diacerein: A New Symptomatic Slow Acting Drug for Osteoarthritis. JK Sci, 8:173-75.

Maski N., Arul K., 2009, Studies on the preparation, characterization and solubility of Cyclodextrendiacerein complex. Int J Pharm and Sci 1:121-35.

Nanjwade VK., Shulka VK., Manvi FV. 2012, Development and characterization of novel pharmaceutical Crystalline complex of lomefloxacin. Int. J. Drug Dev. Res; 1:227-33.

Saifee M., Inamdar N., Dhamecha D., 2009.; Drug polymorphism review; Int. J. Health research, 2:291-366.

Shital S., Shete AS., Doijad RC., Kadam SS., Patil VA., Yadav AV., 2015, Formulation and Solid State Charac-terization of Nicotinamide-based Co-crystals of Fenofibrate.Ind. Jr. Pharm. Sci. 77(3), pp-328-334.

Subhrahmanyam CVS., Thima SA., Devi SK., 2000, Pharmaceutical engineering principle and practices. Vallabhprakashan,: pp-42.

Vippagunta SR., Brittan H., Grant G. 2001, Crystalline solids Advanced drug Delivery reviews, pp 48: 3-26.

Yadav DS., 2012, Preparation and characteri-zation of Diacerein microcrystall. Der Pharmacia Lettre, 4:428-435.

Zhou Z., Li W., Sun W-z., 2016, Resveratrol cocrystals with enhanced solubility and tabletability, J. Pharma. Sci, Vol-509, Issue-1-2, pp.391--399.



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