EVALUATION OF THE EFFECTIVENESS OF FREE NICOTINE PATCH THERAPY IN A CHARITY CLINIC FOR SMOKING CESSATION

SYED WAJID ALI; Sultan Alghadeer Alghadeer; Mohammed N Alarifi; Salmeen D Babelghaith

doi:10.14499/indonesianjpharm27iss4pp226

EVALUATION OF THE EFFECTIVENESS OF FREE NICOTINE PATCH THERAPY IN A CHARITY CLINIC FOR SMOKING CESSATION

SYED WAJID ALI, Sultan Alghadeer Alghadeer, Mohammed N Alarifi, Salmeen D Babelghaith

Abstract

The purpose of this study was to evaluate the efficacy of a free nicotine- patch therapy for smoking cessation in Saudi smokers. A single centered prospective study was carried out in a charity clinic for smoking cessation in Riyadh, Saudi Arabia. A total of 31 subjects who attended the smoking cessation clinic from June 2014 to August 2014 were studied. All participants were male and their mean age was 31.1±6.4 years. The duration of history of smoking was 12.9±6.8 years. The nicotine- patch therapy outcomes were measured at baseline and at 6 weeks after using nicotine- patch therapy. At base line the number of cigarettes per day was 27±10 and carbon monoxide (CO) level was 20.2±8.3. The analyzed statistics revealed that there were significant decreased in the number of cigarette per day (p=0.001) and Carbon Monoxide (CO) level (p=0.001) over 6 weeks of nicotine- patch therapy. After 6 weeks of therapy, abstinence rate was 58 % (verified by CO level) and no serious adverse reactions were documented. The most common side effects were nausea, headache and local irritation sings. In addition, our finding revealed that smokers were likely to suffer from withdrawal symptoms following trying to quit. These withdrawal symptoms include sleep disturbance, loss of concentration and weight gain as well as irritability. Results of this study show that free nicotine-patch therapy is an effective measure for smoking cessation in Saudi population.

Keywords: nicotine patch therapy, smoking cessation clinic, side effects

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References

Al-Doghether MH., 2001. Do we need national guidelines for smoking cessation? Ann Saudi Med. 21: 3-4.

Al-Rifi M N., 2004. Prevalence of smoking and attitude toward smoking cessation among community pharmacists, Saudi Arabia. J Pharm Tecnol. 20:329-333.

Al-Arifi MN., Alkarfy, K . M., Al-Suwayeh, S . A, Aleissa , K . A., Shabana, E . I., Al-Dhuwaili, A . A., Al-Hassan, M . I., 2006. Levels of 210Po in blood, urine and hair of some Saudi smokers. J Radional Nucl Ch 269:115-118.

Bassiony M M., 2009 . smoking Saudi Arabia. Saudi Med J . 30: 876-887.

Batra A., Klingler K., Landfeldt B., Friederich HM., Westin A., Danielsson T., 2005. Smoking reduction treatment with 4-mg nicotine gum: a double-blind, randomized, placebo-controlled study. Clin Pharmacol Ther 78: 689–696.

Chen R., Ku CH., Lu RB., Chou KR., 2002. The impact of smoking cessation programs on smoking-related health belief and rate of quit-smoking among schizophrenic patients. J Med Sci 22: 215–220.

Chou KR., Chen R., Lee JF., Ku CH, Lu R., 2004. The effectiveness of nicotine-patch therapy for smoking cessation in patients with schizophrenia. Int J Nurs Stud 41:321-330.

Dorothy K., Hatsukami Dk., Hughes JR., Pickens RW., Svikis D., 1984. Tobacco withdrawal symptoms: An experimental analysis. Psychopharmacology 84:231 - 236.

Fiore MC., Jaén CR., Baker TB., et al., 2008. Guideline Panel. Treating Tobacco Use and Dependence. 2008 Update. Clinical Practice Guideline. Rockville, MD: U.S. Department of Health and Human Services. Public Health Service, 2008.

Hajek P., Jarvis M J., Belcher M. , Sutherland, G. , Feyerabend ,C., 1989. Effect of smoke-free cigarettes on 24 h cigarette withdrawal: A double-blind placebo-controlled study . Psychopharmacology 97: 99 – 102 .

Jarallah J., Bamgboye E., Al-Ansary L., Kalantan K., 1996. Predictors of smoking among male junior secondary school students in Riyadh, Saudi Arabia. Tob Control ;5:26-9.

Joseph AM., Norman SM., Ferry LH., Prochazka AV., Westman EC., Steele BG., Sherman SE., Cleveland M., Antonnucio DO., Hartman N., McGovern PG., 1996. The safety of transdermal nicotine as an aid to smoking cessation in patients with cardiac disease. N Engl J Med 35:1792–1798.

Lam TH., Abdullah ASM., Chan SS., Hedley AJ .2005. Hong Kong Council on Smoking and Health Smoking Cessation Health Centre (SCHC) Steering Group. Adherence to nicotine replacement therapy versus quitting smoking among Chinese smokers: a preliminary investigation. Psychopharmacology 177: 400–408.

Paoletti P., Fornai E., Maggiorelli F., Puntoni R., Viegi G., Carrozzi L., et al.1996. Importance of baseline cotinine plasma values in smoking cessation results from a double blind study with nicotine patch. Eur Respir 9, 643–651.

Preechawong S., Vathesathogkit K., Suwanratsamee S., 2011, Effects of Tobacco Cessation Counseling Training on Thai Professional Nurses’ Self-efficacy and Cessation Counseling Practices. Pacific Rim Int J Nurs Res 15: 3-12.

Tomson Toftgård M. , Gilljam H1., Helgason R S., 2006. Symptoms in smokers trying to quit. Tob Indu Dis 3:44-51.

Transdermal Nicotine Study Group 1991. Transdermal nicotine for smoking cessation. Six-month results from two multicenter controlled clinical trials. JAMA 266;3133–3138.

World Health Organization 2014. Why tobacco is a public health priority. (Updated 2014; Accessed 2014 November ). Available from URL: http://www.who.int/tobacco/health_priority/en/index.html

Xiao D., Zhong N., Bai C., Xiu Q., Xie C.D., Hu D., Mao Y., PerfekR H., Kruse E., Li Q., Liu JJ., Wang C.,2014. Nicotine gum or patch treatment for smoking cessation and smoking reduction: a multi-centre study in Chinese physicians. Front Med 8:84-90.

DOI: http://dx.doi.org/10.14499/indonesianjpharm27iss4pp226