ANTIOXIDANT ACTIVITY OF DRIED STRAWBERRIES JUICES (Fragaria vesca L.) EMULGEL PREPARATION USING CANDLENUT OIL AND IT’S DIFFUSION

Agitya Resti Erwiyani

doi:10.14499/indonesianjpharm27iss3pp145

ANTIOXIDANT ACTIVITY OF DRIED STRAWBERRIES JUICES (Fragaria vesca L.) EMULGEL PREPARATION USING CANDLENUT OIL AND IT’S DIFFUSION

Agitya Resti Erwiyani

Abstract

Strawberries (Fragaria vesca L.) is a fruit that contains nutrients with many benefits and used as an antioxidant because it contains phenolic, ascorbic acid, pelargonidin-3-glucoside and cyanidin-3-glucoside. In addition, strawberries contain flavonoids, which have high antioxidant capacity. Double emulsion can improve the stability of phenolic compounds from dried strawberry juice. Primary emulsion is dispersed in a gel base (emulgel) and it is expected to produce more stable and better preparation with the ability to release the active ingredient topically. The production of double emulsion preparation (A / M / A) using candlenut oil as the oil phase with high level of total flavonoid and total anthocyanins of formula respectively - were 22.86% and 55.915%. The total flavonoid in dried strawberry juice emulgel was able to pass the membrane shed snake skin with higher flux value than the total flavonoid in the form of emulsion type A / M.

Keywords

formulation; emulgel; strawberry juice; difussion; shed snake skin

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References

Ainurofiq, A., 2006. 'Pengaruh tipe emulsi sederhana dan emulsi ganda terhadap pola pelepasan Natrium Salisilat secara In Vitro', Thesis. Universitas Gadjah Mada, Yogyakarta.

Crecente-Campo, J., Nunes-Damaceno, M., Romero-Rodríguez, M.A., and Vázquez-Odériz, M.L., 2012. Color, Anthocyanin Pigment, Ascorbic Acid and Total Phenolic Compound Determination in Organic Versus Conventional Strawberries (Fragaria × ananassa Duch, cv Selva). Journal of Food Composition and Analysis, 28: 23–30.

Dong, L., Liu, C., Cun, D., and Fang, L., 2015. The effect of rheological behavior and microstructure of the emulgels on the release and permeation profiles of Terpinen-4-ol. European Journal of Pharmaceutical Sciences, 78: 140–150.

Ibrahim, E.-S.A., Hassan, M.A., El-Mahdy, M.M., and Mohamed, A.S., 2007. Formulation and evaluation of quercetin in certain dermatological preparations. J. DRUG DEL. SCI. TECH, 17: 431–436.

Itoh, T., Xia, J., Magavi, R., Nishihata, T., and Rytting, J.H., 1990. Use of Shed Snake Skin as a Model Membrane for in Vitro Percutaneous Penetration Studies: Comparison with Human Skin. Pharmaceutical Research, 7: 1042–1047.

Jin, P., Wang, S.Y., Wang, C.Y., and Zheng, Y., 2011. Effect of cultural system and storage temperature on antioxidant capacity and phenolic compounds in strawberries. Food Chemistry, 124: 262–270.

Khullar, R., Kumar, D., Seth, N., and Saini, S., 2012. Formulation and evaluation of mefenamic acid emulgel for topical delivery. Saudi Pharmaceutical Journal, 20: 63–67.

Kuramoto, M., Tanaka, T., Makita, H., Nakamura, Y., and Yata, N., 1996. Characteristics of Shed Snake Skin Permeability to Indomethacin and Fatty Alcohols. J. Pharm. Pharmacol., 48: 680–684.

Lee, J., Durst, R.W., and Wrolstad, R.E., 2005. Determination of total monomeric anthocyanin pigment content of fruit juices, beverages, natural colorants, and wines by the pH differential method: collaborative study. Journal of AOAC International, 88: 1269–1278.

Lieberman, H. (Editor), 1998. Pharmaceutical Dosage Forms: Disperse Systems, Second Edition, Volume 3, 2 edition. Informa Healthcare, New York.

Mandave, P.C., Pawar, P.K., Ranjekar, P.K., Mantri, N., and Kuvalekar, A.A., 2014. Comprehensive evaluation of in vitro antioxidant activity, total phenols and chemical profiles of two commercially important strawberry varieties. Scientia Horticulturae, 172: 124–134.

Mosquera, L.H., Moraga, G., and Martínez-Navarrete, N., 2012. Critical water activity and critical water content of freeze-dried strawberry powder as affected by maltodextrin and arabic gum. Food Research International, 47: 201–206.

Quino, J., Ruehl, M., Klima, T., Ruiz, F., Will, S., dan Braeuer, A., 2016. Supercritical drying of aerogel: In situ analysis of concentrationprofiles inside the gel and derivation of the effective binary diffusioncoefficient using Raman spectroscopy. J. of Supercritical Fluids, 108: 1–12.

Shin, Y., Liu, R.H., Nock, J.F., Holliday, D., dan Watkins, C.B., 2007. Temperature and relative humidity effects on quality, total ascorbic acid, phenolics and flavonoid concentrations, and antioxidant activity of strawberry. Postharvest Biology and Technology, 45: 349–357.

Vasiljevic, D., Parojcic, J., Primorac, M., dan Vuleta, G., 2006. An investigation into the characteristics and drug release properties of multiple W/O/W emulsion systems containing low concentration of lipophilic polymeric emulsifier. International Journal of Pharmaceutics, 309: 71–77.

Vermeir, L., Sabatino, P., Balcaen, M., Declerck, A., Dewettinck, K., and Martins, J.C., 2016. Effect of molecular exchange on water droplet size analysis in W/O emulsions as determined by diffusion NMR. Journal of Colloid and Interface Science, 463: 128–136.

Wang, Z., Zhang, M., and Wu, Q., 2014. Effects of temperature, pH, and sunlight exposure on the color stability of strawberry juice during processing and storage. LWT - Food Science and Technology, 60: 1174–1178.

Zhu, Q., Nakagawa, T., Kishikawa, A., Ohnuki, K., and Shimizu, K., 2015. In vitro bioactivities and phytochemical profile of various parts of the strawberry (Fragaria × ananassa var. Amaou). Journal of Functional Foods, 13: 38–49.

DOI: http://dx.doi.org/10.14499/indonesianjpharm27iss3pp145