FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ATENOLOL

Uttam Budhathoki; Kshitij Gartoulla; Shailendra Shakya

doi:10.14499/indonesianjpharm27iss4pp196

FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ATENOLOL

Uttam Budhathoki, Kshitij Gartoulla, Shailendra Shakya

Abstract

This study was carried out to develop matrix based transdermal patches containing Atenolol. A 2 factors (HPMC (hydroxyl propyl methyl cellulose) K4M & PVP (Polyvinyl Pyrolidone) 3 level (2³) factorial design was done using Design Expert® which gave 13 experiments. The patches were prepared by Solvent casting method. Propylene glycol (3%) and Tween 80 (6%) were used as plasticizer and permeation enhancer respectively. Physicochemical characteristics and In-Vitro permeation study of formulated transdermal patches were carried out. Contour plot suggested 770 mg of PVP and 265 mg of HPMC K4M in Optimized formulation.

Keywords

Atenolol; Transdermal Patches; In-Vitro permeation study; permeation enhancer; HPMC; PVP

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DOI: http://dx.doi.org/10.14499/indonesianjpharm27iss4pp196