Modulatory effect of Drosera peltata J.E.Sm on development of metabolic syndrome in tumor bearing mice

Raju A, Seeja S Raj, Christina AJM


The purpose of the study conducted was to know the extent of protection over the cancer associated metabolic syndrome development after administration of ethanol and aqueous extracts of Drocera peltata against Dalton’s ascites lymphoma (DAL) and Ehrlich's Ascites Carcinoma (EAC) bearing mice. Animals were divided into thirteen groups with a normal control, EAC control, DAL control, two groups with standard drug 5-Flurouracil 20mg/kg+ DAL & EAC and eight groups with 250 and 500 mg/kg of ethanol and aqueous extracts of D.peltata + EAC & DAL, for respective cell lines. After 24 hours of both tumor cell inoculation, animals were treated with extracts,once in a day for 14 days continuously. The indicators for the development of metabolic syndrome such as changes in blood glucose, serum hormone and lipid profile were found with both cell line bearing mice. Both ethanol and aqueous extracts of D.peltata at doses of 250 and 500mg/kg significantly reduced the elevated blood glucose, hormonal and lipid profile changes. These results confirmed that ethanol and aqueous extracts  can stabilize the tumor induced hormonal, blood glucose and lipid profile changes in tumor bearing mice. This effect might be due to the presence of pharmacologically active phytoconstituents in extracts.


Metabolic syndrome; Ehrlich's Ascites Carcinoma; Dalton’s ascites lymphoma; Drocera peltata; anticancer

Full Text:



Anup M., Sandip K., Batabyal Mrinal KP., 2007. Long- term caffeine induced inhibition of EAC cell progression in relation to gonadal hormone status. Indian J Exp Biology. 45: 347-352.

Douglas RG., Shaw JHF., 1990. Metabolic effects of cancer: Review. Br J Surg. 77: 246-254.

Emily JG., Derek L., 2013. Epidemiology and Molecular Mechanisms Tying Obesity, Diabetes, and the Metabolic Syndrome with Cancer. Diabetes care. 36: S233-239.

Feinleib M., 1983. Review of the epidemiological evidence for a possible relationship between hypocholesterolemia and cancer. Cancer Res. 43: 2503-2507.

Gallagher EJ., LeRoith D., 2013. Epidemiology and Molecular Mechanisms Tying Obesity, Diabetes, and the Metabolic Syndrome with Cancer. Diabetes Care. 36(Suppl 2):S233-S239.

Kiran SP., 2013. Beneficial effects of herbs, spices and medicinal plants on the metabolic syndrome, brain and cognitive function. Cent. Nerv. Syst. Agents Med. Chem. 13: 13-29.

Malaya Gupta., Upal KM., Ramanathan SK., Thangavel S., Madgula LMV., 2004. Antitumor Activity and antioxidant status of Caesalpinia bonducella against Ehrlich Ascites Carcinoma in Swiss albino mice. J Pharmacol Sci. 94: 177 – 184.

Pooja P., Sushil KJ., Subhashini Y., 2009. Metabolic Syndrome and Cancer. Metabolic syndrome and related disorders. 7(4): 279 – 288.

Prachi G., Haruyo I., Nikita M., Gautam S., Bharat BA., 2007. Ancient medicine to modern medicine: Ayurvedic concepts of health and their role in inflammation and cancer. Journal of the Society for Integrative Oncology. 5: 1-16.

Raju A., Christina AJM., Anita Murali., 2013b. In Vitro Antioxidant and anticancer activity studies on Drosera indica L. (Droseraceae). Adv Pharm Bull. 3(1): 115-120.

Raju A., Christina AJM., Anita Murali., 2013a. Effect of Drosera burmannii vahl on metabolic syndrome developed in Ehrlich Ascites Carcinoma (EAC) bearing mice. Phytopharmacology. 4(1): 53-60.

Rezvanfar MA., Sadrkhanlou RA., Ahmadi A., Shojaei-Sadee H., Rezvanfar MA., Mohammadirad A., Salehnia A., Abdollahi M., 2008.

Protection of cyclophosphamide-induced toxicity in reproductive tract histology, sperm characteristics, and DNA damage by an herbal source; evidence for role of free-radical toxic stress. Human Experimental Toxicology. 27: 901-910.

Sanyal U., Samanta S., Pain A., Datta S., 2002. Interleukin -4,-5 and -13 emerging therapeutic targets in allergic disease. J. Exp. Clin. Cancer Res. 21: 609.

Zhou JR., Li L., Pan W., 2007. Dietary soy and tea combinations for prevention of breast and prostate cancers by targeting metabolic syndrome elements in mice. The American journal of clinical nutrition. 86(3): s882-s888.



  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Indonesian J Pharm indexed by:

analytics View My Stats