PHYSICAL CHARACTERIZATION OF IBUPROFEN-STEARIC ACID BINARY MIXTURE DUE TO COMPRESSION FORCE
Aim of this research is to determine physical characteristic of ibuprofen-stearic acid due to compression force. Binary mixture of ibuprofen-stearic acid with weight ratio of 4:6, 5:5, and 6:4 was compressed under various compression force using hydraulic press with 13mm diameter flat punch.Identification of solid state interaction between these two components was performed by Hot Stage Microscopy (HSM). Physical characterization has been studied byDifferential Thermal Analysis (DTA), X-ray Powder Diffraction (XRPD), Scanning Electron Microscopy (SEM), and (Fourier Transform Infrared (FT-IR) spectroscopy. According to hardness measurement, 4:6 weight ratio has the highest tensile strength on 170.6N/cm2 under 19.93kN compression force. Interaction identification by HSM showed single blank line that indicates eutectic formation. Thermal analysis of DTA also revealed eutectic formation upon compression whichthe endotermic peak of ratio of 4:6has the lowest melting temperature of 53.2°C. X-ray diffraction of three peaksgenerally showed that peak intensity decreases as compression force increases, but at particular point it begins to increase again. Sintering phenomenon at the surface of compressed tablet was observed from SEM analysis. FT-IR study confirms the formation of simple eutectic.
Key words: ibuprofen, stearic acid, binary mixture, compression force, physical characterization
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Adeyeye MJ. and BrittainHG., 2008. Chapter 4.1. Overview of Solid Dosage Form Preformulation Program in Preformulation in Solid Dossage Form Development, edited by Brittain HG., Informa Health Care Inc., New York, USA, pp 347-355.
Ali W., Williams AC., and Rawlinson CF., 2010. Stochiometrically governed molecular interactions in drug: Poloxamer solid dispersion. Int. J. Pharm. 391, pp. 162-8.
Bandyopadhyay R., Jon S., Gregory EA., Michael H., 2005. Application of Powder X-ray Diffraction in Studying the Compaction behavior of Bulk Pharma- ceuticals Powder. J.Pharm.Sci. 94: 2520-2530.
Bergman L., Bandeline F., 1965. Compatibility Studies Between Carbamazepine and Tablet Excipients Using Thermal and Non-Thermal Methods. J.Pharm.Sci. 54:445.
Bi M., Sung JH., Kenneth RM., 2002. Mechanism of Eutectic Formation Upon Compaction and Its Effects on Tablet Properties. Therm.Act. 404: 213-226.
Davis RE., Lorimer KA., Wilkowski MA., Rivers JH., Wheeler KA., and Bowers J., 2004. Studies of phase relationships in cocrystal systems. ACA Trans.39: 41-61.
Hosaka S, Sato M., Ozawa Y., Hamada C., Takahashi Y., Kitamori N., 2005. Effect of Compression on Interaction between 1,4-dihydropyridineCompounds and Lactose Monohydrate. Chem.Pharm.Bull. 53(5): 503-507.
Lerdkanchanaporn S., Dollimore D., Evans SJ., 2001. Phase diagram for the mixtures of ibuprofen and stearic acid. Therm. Act. 367 : 1-8.
Putra OD., Nugrahani I., Ibrahim S., Uekusa H., 2012. Semi-crystalline and Co-crystal of Paracetamol Formation. JMS17(2): 83-88.
Rippi M., Tanninen VP., Yliruusi J., 2000. Effect of Compression Force on Crystal Properties of Erythromycin Acitrate Tablets. Eur J. Pharm. Biopharm. 50: 365-371.
Setyawan D., Sumirtapura YC., Suwandhi SN., 2009. Effect of Compression Force on Crystal Properties of Erythromycin Stearate. Proceedingin Int.Conf Med Chem
Swarbrick J. and Boylan JC., 1996. Sintering in Pharmaceutics in Encyclopedia of Pharma-ceutical Technology Volume 14th 2nd Edition, edited by Li LC. and Li JH., Marcel Dekker, New York, USA, pp 87-101.
Wang J., Davidovich M., Desai D., Bu D., Hussain M., Morris M., 2010. Solid-State Interactions of a Drug Substance and Excipients and Their Impact on Tablet Dissolution: A Thermal-Mechanical Facilitated Process-Induced Transfor-mation or PIT. J. Pharm. Sci. 99 (9): 3849-3862.
Wu C., Best SM., Bentham AC., Hancock BC.,Bonfield W., 2005. A simple predictive model for the tensile strength of binary tablets. Eur. J. Pharm. Sci. 25: 331-336.
Yoshinari T., Forbes T.R., York P., Kawashima Y., 2003. The Improved Compaction Properties of Mannitol After a Moisture Induced Polymorphic Transition. Int. J. Pharm.258: 121-131.
Zaini E., Halim A., Soewandhi SN., Setyawan D. 2011. Solubility Rate Improvement of Trimethoprim using Co-crystallization Method with Nicotinamide. JFI 5(4):205-212.
Zalac S, Khan MZI., Gabelica V., Tudja M., Mestrovic E. and Romih M., 1998. Paracetamol-Propyphenazone Interaction and Formulation Difficulties Associated with Eutectic Formation in Combination Solid Dosage Forms. Chem. Pharm. Bull. 47(3): 302-307.
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