ROLE OF CHITOSAN, CARBOXY METHYL CELLULOS, POLYVINYL PYRROLIDONE, KYRON T134 AND PRIMOGEL TO DESIGN THE MOUTH DISINTEGRATING TELMISARTAN TABLET WITH EXTENDED RELEASE PROFILE
The Mouth Disintegrating Extended Release Telmisartan (MDERT) tablets are designed for adequate pharmacokinetic profile to avoid the unusual peaks and troughs. Although, there are extensive advance techniques used to deliver drugs. But oral route is still remains effective in most of the therapeutical situations. Thus we aimed this study to formulate a dosage form with dual character of orodispersion as well as extended effectiveness. MDERTS dosage form was prepared by direct compression method. The major components of this preparation were Telmisartan (TLM), Carboxy methyl cellulose polyvinyl Pyrrolidone, Chitosan, Talc, Mg-stearate, Lactose. While the equipments used to study the parameters were FTIR (IR Prestige 21 Shimadzu), Thermal Analyzer (SDT Q600), Oven (IM-30 IRMECO Gmb), Spectrophotometer UV 1700 (Shimadzu), pH meter (Jenway 3510), Friabilator (Pharma test, Germany), Weight balance (Shimadzu A x200) and Disintegration Apparatus (Pharma test). The MDERTS dosage form was characterized with different determinants- Bulk density, Tapped density, Angle of repose, Carrs index, Hausners ratio, Thickness, Weight variation, Hardness, Weight variation, Wetting time, Wetting volume, Water absorption ratio, Drug content, In vitro drug release, In vitri disintegration time etc. The final results were tabulated to illustrate the finding. While, the drug release curves of all 6 formulations upto 12 hrs, DSC spectra of TLM, Kyron T134, Primogel, TLM+Kyron T134+Primogel, Chitosan, CMC and different excepients are presented as comprehensive scientific figures. In conclusion, the determinants of MDERTS can be adjusted with the acceptable range to improve the biological efficiency. DSC and FTIR spectroscopic studies indicate the compatibility of drugs with each other and with excipients. Moreover, the formulation F2 containing more than 10% of Kyron T had shown best results. Whereas, the overall results had shown that Kyron T containing tablets had best, in vitro dispersion time, wetting time and wetting volume, water absorption ratio. In addition of that the rheological properties of blend powder are modifiable and improvable to meet the quality standard specifications for MDERTS. The order in which superdisintegrants and polymers had produced desirable effect is Kyron T134 > Kyron T134134 + primogel > primogel and for polymers chitosan> chitosan+CMC> chitosan +PVP> CMC> CMC+PVP> PVP. Thus, Kyron T is the best superdisintegrant of others which were used in present study and direct compression method is the best used to prepare extended release mouth disintegrating tablets.
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