ROLE OF CHITOSAN, CARBOXY METHYL CELLULOS, POLYVINYL PYRROLIDONE, KYRON T134 AND PRIMOGEL TO DESIGN THE MOUTH DISINTEGRATING TELMISARTAN TABLET WITH EXTENDED RELEASE PROFILE
The Mouth Disintegrating Extended Release Telmisartan (MDERT) tablets are designed for adequate pharmacokinetic profile to avoid the unusual peaks and troughs. Although, there are extensive advance techniques used to deliver drugs. But oral route is still remains effective in most of the therapeutical situations. Thus we aimed this study to formulate a dosage form with dual character of orodispersion as well as extended effectiveness. MDERTS dosage form was prepared by direct compression method. The major components of this preparation were Telmisartan (TLM), Carboxy methyl cellulose polyvinyl Pyrrolidone, Chitosan, Talc, Mg-stearate, Lactose. The MDERTS dosage form was characterized with different determinants. While, the drug release curves of all 6 formulations upto 12h, DSC spectra of TLM, Kyron T134, Primogel, TLM+Kyron T134+Primogel, Chitosan, CMC and different excepients are presented as comprehensive scientific figures. DSC and FTIR spectroscopic studies indicate the compatibility of drugs with each other and with excipients. Moreover, the formulation F2 containing more than 10% of Kyron T had shown best results. Whereas, the overall results had shown that Kyron T containing tablets had best, in vitro dispersion time, wetting time and wetting volume, water absorption ratio. The order in which superdisintegrants and polymers had produced desirable effect is Kyron T134 > Kyron T134134 + primogel > primogel and for polymers chitosan> chitosan+CMC> chitosan +PVP> CMC> CMC+PVP> PVP. Thus, Kyron T is the best superdisintegrant of others which were used in present study and direct compression method is the best used to prepare extended release mouth disintegrating tablets.
Allen LV Jr. Remington. 2012. The Science and Practice of Pharmacy: from the past into the future. Int J Pharm Compd. 16 (5): 358-62.
Bankars.K, Chaudhari A.V, Mahale N.B and Chaudhari S.R. 2014. A Review On Orodispersible Tabletsprepared Using Spray Dried Sustained Release Microparticles. Journal of Advanced Drug Delivery. 1(2): 82-95.
Belal TS, Mahrous MS, Abdel-Khalek MM, Daabees HG, Khamis MM. 2014. Validated spectrofluorimetric determination of two pharmaceutical antihypertensive mixtures containing amlodipine besylate together with either candesartan cilexetil or telmisartan. Luminescence. 29(7): 893-900. doi: 10.1002/bio.2638
Hafez HM, Elshanawane AA, Abdelaziz LM, Kamal MM. Quantitative Determination of three Angiotensin-II-receptor Antagonists in Presence of Hydrochlorothiazide by RP-HPLC in their Tablet Preparations. Iran J Pharm Res. 12(4): 635-43.
Ieva E, Trapani A, Cioffi N, Ditaranto N, Monopoli A, Sabbatini L. 2009. Analytical characterization of chitosan nanoparticles for peptide drug delivery applications. Anal Bioanal Chem. 393(1): 207-15. doi: 10.1007/s00216-008-2463-4
Lepek P, Sawicki W, Wlodarski K, Wojnarowska Z, Paluch M, Guzik L. 2013. Effect of amorphization method on TLM solubility and the tableting process. Eur J Pharm Biopharm. 83(1):114-21. doi: 10.1016/j.ejpb.2012.09.019. PubMed PMID: 23085331.
Rao RN, Guru Prasad K, Gangu Naidu Ch, Maurya PK. 2011. Development of a validated liquid chromatographic method for determination of related substances of TLM in bulk drugs and formulations. J Pharm Biomed Anal. 56(3): 471-8. doi: 10.1016/j.jpba.2011.05.043. PubMed PMID: 21719227.
Ravi Kumar MNV, Muzzarelli RAA, Muzzarelli C, Sashiwa H, Domb AJ. 2004. Chitosan Chemistry and Pharmaceutical Perspectives. Chem. Rev. 104: 6017–6084.
Sekar V, Chellan VR. 2008. Immediate release tablets of TLM using superdisintegrant-formulation, evaluation and stability studies. Chem Pharm Bull (Tokyo). 56(4): 575-7. PubMed PMID: 18379110.
Shanmugam S. 2015. Granulation techniques and technologies: recent progresses. Bioimpacts. 2015;5(1): 55-63. doi: 10.15171/bi.2015.04
Zhong L, Zhu X, Luo X, Su W. 2013. Dissolution properties and physical characterization of TLM-chitosan solid dispersions prepared by mechanochemical activation. AAPS PharmSciTech. 14(2): 541-50. doi: 10.1208/s12249-013-9937-1. PubMed PMID: 23430728; PubMed Central PMCID: PMC3665993.
- There are currently no refbacks.
Copyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Indonesian J Pharm indexed by:
View My Stats