SYNTHESIS OF TETRAHYDROHEXAGAMAVUNON-5 AND TETRAHYDROHEXAGAMAVUNON-7

Ritmaleni Ritmaleni; Ian Praditya; Haryono Wibowo; Sardjiman Sardjiman

doi:10.14499/indonesianjpharm26iss2pp103

SYNTHESIS OF TETRAHYDROHEXAGAMAVUNON-5 AND TETRAHYDROHEXAGAMAVUNON-7

Ritmaleni Ritmaleni, Ian Praditya, Haryono Wibowo, Sardjiman Sardjiman

Abstract

Synthesis of Tetrahydrohexagamavunon-5 (THHGV-5) and Tetrahydrohexagamavunone-7 (THHGV-7) were prepared by catalytic hydrogenation reaction on Hexagamvunon-5 (HGV-5) and Hexagamavunone-7 (HGV-7) by using gas H₂as source of hydrogen gas, Pd/C 10 % as metal catalyst and methanol as solvent at room temperature. The products were characterized by IR Spectroscopy, Gas Chromatography-Mass Spectroscopy (GCMS), 1D-NMR (¹H-NMR and ¹³C-NMR) and 2D-NMR (¹H-¹³C HMQC) Spectroscopy to determine the product structure molecules. According to the data of IR, GC-MS, ¹H-NMR, ¹³C-NMR and ¹H-¹³C HMQC spectra, the products are THHGV-5 and THHGV-7 as white crystalline powders.

Key words:Tetrahydrohexagamavunon-5, Tetrahydrohexagamavunone-7, Hexagamvunon-5, Hexagamavunone-7

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DOI: http://dx.doi.org/10.14499/indonesianjpharm26iss2pp103